Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

Protease biology is intimately linked to the functional consequences of substrate cleavage
events. Human caspases are a family of 12 fate-determining cysteine proteases that are best …

In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

The endoplasmic reticulum is an organelle with multiple functions. The synthesis of
transmembrane proteins and proteins that are to be secreted occurs in this organelle. Many …

Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic
apoptosis, regulates physiological cell death and pathological tissue degeneration. Its …

Highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus
2 (refs.,)(SARS-CoV-2), Middle East respiratory syndrome coronavirus (MERS-CoV) and …

Influenza A virus (IAV) is a lytic virus in primary cultures of many cell types and in vivo. We
report that the kinase RIPK3 is essential for IAV-induced lysis of mammalian fibroblasts and …

Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the
entire digestive tract. A single-nucleotide polymorphism (SNP) encoding a missense variant …

The apoptosome is a platform that activates apical procaspases in response to intrinsic cell
death signals. Biochemical and structural studies in the past two decades have extended …

Caspases are intracellular proteases that propagate programmed cell death, proliferation,
and inflammation. Activation of caspases occurs by a conserved mechanism subject to strict …