Immunotherapy has made remarkable strides in cancer therapy over the past decade.
However, such emerging therapy still suffers from the low response rates and immune …

NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Immuno-oncology approaches have entered clinical practice, with tremendous progress
particularly in the field of T cell-engaging therapies over the past decade. Herein, we provide …

The gut microbiota influences the health of the host, especially with regard to gut immune
homeostasis and the intestinal immune response. In addition to serving as a nutrient …

Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …

Checkpoint blockade immunotherapy relies on energized cytotoxic T cells attacking tumour
tissue systemically. However, for many cancers, the reliance on T cell infiltration leads to low …

Tumor immunotherapy, such as PD-1/PD-L1 blockade, has shown promising clinical efficacy
in patients with various types of tumors. However, the response to PD-1/PD-L1 blockade in a …

Combination therapy that could better balance immune activation and suppressive signals
holds great potential in cancer immunotherapy. Herein, we serendipitously found that the pH …

X-rays are widely applied in clinical medical facilities for radiotherapy (RT) and biomedical
imaging. However, the sole use of X-rays for cancer treatment leads to insufficient radiation …

Lead toxicity is a major public health issue in developed and developing countries. Both
acute and chronic lead exposure has the potential to cause many deleterious systematic …