Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate.
However, fundamental gaps remain in our understanding of the underlying pathological …

The pulmonary vasculature is comprised of three anatomic compartments connected in
series: the arterial tree, an extensive capillary bed, and the venular tree. Although in general …

Clinical pulmonary hypertension is characterized by a sustained elevation in pulmonary
arterial pressure. Pulmonary vascular remodeling involves structural changes in the normal …

We determined the distribution of ETA and ETB receptors in pulmonary arteries from
pulmonary hypertensive patients and control subjects, using in vitro autoradiography, and …

Pulmonary vascular remodelling is an important pathological feature of pulmonary
hypertension, leading to increased pulmonary vascular resistance and reduced compliance …

Abstract Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that
has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth …

Endothelin receptor antagonists (ERAs) have been developed to block the effects of
endothelin-1 (ET-1) in a variety of cardiovascular conditions. ET-1 is a powerful …

Background—The dual endothelin-receptor antagonist bosentan has been reported to
improve pulmonary arterial hypertension, but the role of endothelins in the pathogenesis of …

Previous studies have suggested a genetic component in susceptibility to hypoxia-induced
pulmonary hypertension. We therefore estimated the prevalence of high-altitude pulmonary …

Sleep apnea (SA) is a very prevalent sleep breathing disorder mainly characterized by
intermittent hypoxemia and sleep fragmentation, with ensuing systemic inflammation …