Schistosomiasis—from immunopathology to vaccines
DP McManus, R Bergquist, P Cai… - Seminars in …, 2020 - Springer
Schistosomiasis (bilharzia) is a neglected tropical disease caused by trematode worms of
the genus Schistosoma. The transmission cycle involves human (or other mammalian) water …
the genus Schistosoma. The transmission cycle involves human (or other mammalian) water …
[HTML][HTML] Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity
Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a
Th2-dominated immune response, but stimulation of immunoregulatory cell populations …
Th2-dominated immune response, but stimulation of immunoregulatory cell populations …
[HTML][HTML] Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases
R Gencheva, Q Cheng, ESJ Arner - Free Radical Biology and Medicine, 2022 - Elsevier
Human thioredoxin reductase (TrxR) is a selenoprotein with a central role in cellular redox
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …
Review series on helminths, immune modulation and the hygiene hypothesis: immunity against helminths and immunological phenomena in modern human …
Although the molecules and cells involved in triggering immune responses against parasitic
worms (helminths) remain enigmatic, research has continued to implicate expansions of T …
worms (helminths) remain enigmatic, research has continued to implicate expansions of T …
Excretory/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum
F Liu, SJ Cui, W Hu, Z Feng, ZQ Wang… - Molecular & Cellular …, 2009 - ASBMB
Schistosomes are the causative agents of schistosomiasis, one of the most prevalent and
serious of the parasitic diseases that currently infects∼ 200 million people worldwide …
serious of the parasitic diseases that currently infects∼ 200 million people worldwide …
Immunological and biochemical interplay between cytokines, oxidative stress and schistosomiasis
The host–parasite schistosome relationship relies heavily on the interplay between the
strategies imposed by the schistosome worm and the defense mechanisms the host uses to …
strategies imposed by the schistosome worm and the defense mechanisms the host uses to …
Glycomic Analysis of Life Stages of the Human Parasite Schistosoma Mansoni Reveals Developmental Expression Profiles of Functional and Antigenic Glycan Motifs …
CH Smit, A van Diepen, DL Nguyen, M Wuhrer… - Molecular & Cellular …, 2015 - ASBMB
Glycans present on glycoproteins and glycolipids of the major human parasite Schistosoma
mansoni induce innate as well as adaptive immune responses in the host. To be able to …
mansoni induce innate as well as adaptive immune responses in the host. To be able to …
Schistosoma genomics: new perspectives on schistosome biology and host-parasite interaction
ZG Han, PJ Brindley, SY Wang… - Annual review of …, 2009 - annualreviews.org
Schistosomiasis, caused mainly by Schistosoma japonicum, S. mansoni, and S.
hematobium, remains one of the most prevalent and serious parasitic diseases worldwide …
hematobium, remains one of the most prevalent and serious parasitic diseases worldwide …
Immunity induced by the radiation‐attenuated schistosome vaccine
JP Hewitson, PA Hamblin… - Parasite immunology, 2005 - Wiley Online Library
As a paradigm for the development of a vaccine against human schistosomiasis, the
radiation‐attenuated (RA) vaccine has enabled the dissection of different immune …
radiation‐attenuated (RA) vaccine has enabled the dissection of different immune …
Schistosomiasis pulmonary arterial hypertension
JP Sibomana, A Campeche, RJ Carvalho-Filho… - Frontiers in …, 2020 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in
right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic …
right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic …