Schistosomiasis (bilharzia) is a neglected tropical disease caused by trematode worms of
the genus Schistosoma. The transmission cycle involves human (or other mammalian) water …

Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a
Th2-dominated immune response, but stimulation of immunoregulatory cell populations …

Human thioredoxin reductase (TrxR) is a selenoprotein with a central role in cellular redox
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …

Although the molecules and cells involved in triggering immune responses against parasitic
worms (helminths) remain enigmatic, research has continued to implicate expansions of T …

Schistosomes are the causative agents of schistosomiasis, one of the most prevalent and
serious of the parasitic diseases that currently infects∼ 200 million people worldwide …

The host–parasite schistosome relationship relies heavily on the interplay between the
strategies imposed by the schistosome worm and the defense mechanisms the host uses to …

Glycans present on glycoproteins and glycolipids of the major human parasite Schistosoma
mansoni induce innate as well as adaptive immune responses in the host. To be able to …

Schistosomiasis, caused mainly by Schistosoma japonicum, S. mansoni, and S.
hematobium, remains one of the most prevalent and serious parasitic diseases worldwide …

As a paradigm for the development of a vaccine against human schistosomiasis, the
radiation‐attenuated (RA) vaccine has enabled the dissection of different immune …

Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in
right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic …