Glycolysis: A fork in the path of normal and pathological pregnancy

R Gou, X Zhang - The FASEB Journal, 2023 - Wiley Online Library
Glucose metabolism is vital to the survival of living organisms. Since the discovery of the
Warburg effect in the 1920s, glycolysis has become a major research area in the field of …

[HTML][HTML] Epigenetic modifications of placenta in women with gestational diabetes mellitus and their offspring

Y Yi, T Wang, W Xu, SH Zhang - World Journal of Diabetes, 2024 - ncbi.nlm.nih.gov
Gestational diabetes mellitus (GDM) is a pregnancy-related complication characterized by
abnormal glucose metabolism in pregnant women and has an important impact on fetal …

Shoutai Wan improves embryo survival by regulating aerobic glycolysis of trophoblast cells in a mouse model of recurrent spontaneous abortion

X Liang, S Tang, D Li, Y Song, M He… - Evidence‐Based …, 2022 - Wiley Online Library
Background. During embryo implantation, the blastocyst exhibits a high capacity for aerobic
glycolysis, which results in a unique microenvironment of high lactate/low pH at the maternal …

Mucin1 induced trophoblast dysfunction in gestational diabetes mellitus via Wnt/β-catenin pathway

SS Cui, P Zhang, L Sun, YLL Yuan, J Wang… - Biological Research, 2023 - Springer
Background To elucidate the role of Mucin1 (MUC1) in the trophoblast function (glucose
uptake and apoptosis) of gestational diabetes mellitus (GDM) women through the Wnt/β …

METTL3 regulates glucose transporter expression in placenta exposed to hyperglycemia through the mTOR signaling pathway

J Ning, J Huai, S Wang, J Yan, R Su, M Zhang… - Chinese Medical …, 2024 - mednexus.org
Background: Alterations in the placental expression of glucose transporters (GLUTs), the
crucial maternal-fetal nutrient transporters, have been found in women with hyperglycemia …

Feto-placental endothelial dysfunction in Gestational Diabetes Mellitus under dietary or insulin therapy

JJ Wang, X Wang, Q Li, H Huang, QL Zheng… - BMC Endocrine …, 2023 - Springer
Objective Gestational diabetes mellitus (GDM) is a serious complication in pregnancy.
Despite controlling the plasma glucose levels with dietary intervention (GDM-D) or insulin …

High Glucose Promotes Inflammation and Weakens Placental Defenses against E. coli and S. agalactiae Infection: Protective Role of Insulin and Metformin

R Jiménez-Escutia, D Vargas-Alcantar… - International Journal of …, 2023 - mdpi.com
Placentas from gestational diabetes mellitus (GDM) patients undergo significant metabolic
and immunologic adaptations due to hyperglycemia, which results in an exacerbated …

Role of melatonin receptor 1B gene polymorphism and its effect on the regulation of glucose transport in gestational diabetes mellitus

L Wei, Y Jiang, P Gao, J Zhang, X Zhou, S Zhu… - Journal of Zhejiang …, 2023 - Springer
Abstract Melatonin receptor 1B (MT2, encoded by the MTNR1B gene), a high-affinity
receptor for melatonin, is associated with glucose homeostasis including glucose uptake …

Hyperglycemia in pregnancy-associated oxidative stress augments altered placental glucose transporter 1 trafficking via AMPKα/p38MAPK Signaling Cascade

S Wang, J Ning, J Huai, H Yang - International Journal of Molecular …, 2022 - mdpi.com
GLUT1, being a ubiquitous transporter isoform, is considered primarily responsible for
glucose uptake during glycolysis. However, there is still uncertainty about the regulatory …

IRF2BP2 attenuates gestational diabetes mellitus by activating AMPK signaling

S Zhang, Y Wang, L Zhou, Z Yu, A Gao - Tropical Journal of Pharmaceutical …, 2022 - ajol.info
Purpose: To investigate the role of interferon regulatory factor 2 binding protein 2 (IRF2BP2)
in gestational diabetes mellitus (GDM). Methods: Mice were injected intraperitoneally with …