Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Adult skeletal muscle can regenerate in response to muscle damage. This ability is
conferred by the presence of myogenic stem cells called satellite cells. In response to stimuli …

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite
advances in genetic and pharmacological disease-modifying treatments, its management …

Lactate exchange between glycolytic and oxidative cancer cells is proposed to optimize
tumor growth. Blocking lactate uptake through monocarboxylate transporter 1 (MCT1) …

Store-operated calcium entry (SOCE) is activated in response to depletion of the
endoplasmic reticulum-Ca 2+ stores following stimulation of plasma membrane receptors …

Transient receptor potential (TRP) channels are recently identified proteins that form a
versatile family of ion channels, the majority of which are calcium permeable and exhibit …

Cardiac myocyte function is dependent on the synchronized movements of Ca2+ into and
out of the cell, as well as between the cytosol and sarcoplasmic reticulum. These …

Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation
in older adults and currently lack viable treatment strategies. Here we find that sphingolipids …

Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of Ca 2+ stores within the endoplasmic reticulum (ER) and contributes …

Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, is a severe
muscle disorder, causing muscle weakness, loss of independence, and premature death …