Alterations in protein ubiquitination and hypoxia-inducible factor (HIF) signaling both
contribute to tumorigenesis and tumor progression. Ubiquitination is a dynamic process that …

Photodynamic therapy (PDT) has become a promising method of cancer treatment due to its
unique properties, such as noninvasiveness and low toxicity. The efficacy of PDT is …

Hypoxia‐inducible factor 2α (HIF2α) plays a pivotal role in breast tumor growth and
metastasis. However, the regulatory mechanisms of HIF2α protein stability remain poorly …

Metabolic diseases and their complications impose health and economic burdens
worldwide. Evidence from past experimental studies and clinical trials suggests our body …

Mutations in E3 ubiquitin ligase UBE3B have been linked to Kaufman Oculocerebrofacial
Syndrome (KOS). Accumulating evidence indicates that UBE3B may play an important role …

Long noncoding RNAs (lncRNAs) are noncoding RNAs with length greater than 200 nt. The
biological roles and mechanisms mediated by lncRNAs have been extensively investigated …

Protein homeostasis is predominantly governed through post-translational modification
(PTM). UBE3B, identified as an oncoprotein, exhibits elevated protein levels in breast …

Constitutive ERK1/2 activation has been frequently observed in pancreatic adenocarcinoma
(PDAC). How ERK1/2 activation status been potentiated and maintained by epigenetic …

Hypoxia as one of the most prominent features in tumors, has presented negative effects on
tumor therapies including photodynamic therapy, radiotherapy, and chemotherapies …

Renal fibrosis is a common outcome of various renal injuries, leading to structural
destruction and functional decline of the kidney, and is also a critical prognostic indicator …