Cancer is one of the major causes of mortality and morbidity worldwide. Substantial
research efforts have been made to develop new chemical entities with improved anticancer …

Five-membered heteroaromatic rings, in particular, have gained prominence in medicinal
chemistry as they offer enhanced metabolic stability, solubility and bioavailability, crucial …

Thiazolidinedione (TZD) containing derivatives have been proved to be promising
anticancer agents in preclinical and clinical evaluation phases. Hybrid molecules not just …

Recently, we have reported that non-hydroxamate thiazolidinedione (TZD) analogs are
capable of inhibiting human deacetylase 4 (HDAC4). This study aims at the dissection of the …

A series of 2-phenylamino-3-acyl-1, 4-naphtoquinones were evaluated regarding their in
vitro antiproliferative activities using DU-145, MCF-7 and T24 cancer cells. Such activities …

Histone deacetylases are well-established target enzymes involved in the pathology of
different diseases including cancer and neurodegenerative disorders. The approved HDAC …

Cancer is the most destructive and fatal disease, representing an urgent medical challenge
to the world. The discovery of a new anticancer candidate may help reduce or eliminate this …

Cancer is the most serious disease afflicting humans and a primary cause of death on a
global scale. Chemotherapy continues to be one of the most essential cancer treatments, in …

Spinal muscular atrophy, a neurodegenerative recessive disease, is one of the leading
genetic causes of death in early infancy and childhood worldwide, having an etiology in a …

Noninvasive techniques for disease imaging and targeted therapy allow for personalized
treatment regimens. Radiometal-based imaging and therapeutic agents are expanding due …