Advances in immunotherapy have led to durable and long‐term benefits in a subset of
patients across a number of solid tumor types. Understanding of the subsets of patients that …

Gene-engineered immune cell therapies have partially transformed cancer treatment, as
exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic …

Cytokine-inducible SH2-containing protein (CIS; encoded by the gene CISH) is a key
negative regulator of interleukin-15 (IL-15) signaling in natural killer (NK) cells. Here, we …

Human adaptive-like natural killer (NK) cells express low levels of FcεRIγ (FcRγ−/low) and
are reported to accumulate during COVID-19 infection; however, the mechanism underlying …

Current doctrine is that microvascular inflammation (MVI) triggered by a transplant-recipient
antibody response against alloantigens (antibody-mediated rejection) is the main cause of …

Rejection remains the main cause of premature graft loss after kidney transplantation,
despite the use of potent immunosuppression. This highlights the need to better understand …

Inhibitory signaling during natural killer (NK) cell education translates into increased
responsiveness to activation; however, the intracellular mechanism for functional tuning by …

Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt's
expression in most immune cells, either at baseline or upon activation, reflects its …

Obesity and associated liver diseases (Non Alcoholic Fatty Liver Disease, NAFLD) are a
major public health problem with increasing incidence in Western countries (25% of the …

Energy metabolism plays a crucial role in the immune system. In addition to providing vital
energy for cell growth, reproduction and other cell activities, the metabolism of nutrients such …