The field of gene therapy has made considerable progress over the past several years.
Adeno-associated virus (AAV) vectors have emerged as promising and attractive tools for in …

Presumably because of the selective pressure exerted by the immune system, many viruses
have evolved proteins that interfere with antigen presentation by major histocompatibility …

A systematic quantitative analysis of temporal changes in host and viral proteins throughout
the course of a productive infection could provide dynamic insights into virus-host …

The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits
natural killer (NK) cell–mediated lysis by interacting with CD94/NKG2A receptors. Surface …

▪ Abstract Classical class I molecules assemble in the endoplasmic reticulum (ER) with
peptides mostly generated from cytosolic proteins by the proteasome. The activity of the …

The cell surface display of peptides by MHC class I molecules to lymphocytes provides the
host with an important surveillance mechanism to protect against invading pathogens …

This review describes the diverse array of pathways and molecular targets that are used by
viruses to elude immune detection and destruction. These include targeting of pathways for …

Little is known about the mechanism by which IFNs inhibit human cytomegalovirus (HCMV)
replication. Indeed, infection of fibroblasts with HCMV initiates the expression of a subset of …

In this review, we discuss recent data from our laboratory that address two aspects of major
histocompatibility complex (MHC) class I‐restricted antigen processing. First, we consider …

Human cytomegalovirus (HCMV) persists as a subclinical, lifelong infection in the normal
human host, but reactivation from latency in immunocompromised subjects results in serious …