Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …

Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

Glycosylation is a common and widespread post-translational modification that affects a
large majority of proteins. Of these, a small minority, about 20, are specifically modified by …

Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and variously implicated in …

Regeneration of adult mammalian central nervous system (CNS) axons is abortive, resulting
in inability to recover function after CNS lesion, including spinal cord injury (SCI). Here, we …

Glycosaminoglycans (GAGs) are complex carbohydrates that are ubiquitously present on
the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens …

Coronary artery disease is the main cause of death worldwide and accelerated by increased
plasma levels of cholesterol-rich low-density lipoprotein particles (LDL). Circulating PCSK9 …

Heparan sulfate (HS) polysaccharides are major constituents of the extracellular matrix,
which are involved in myriad structural and signaling processes. Mature HS polysaccharides …

Schizophrenia and bipolar disorder are major psychiatric disorders with high heritability and
overlapping genetic variance. Here we perform a genome-wide association study in an …

The cartilage growth plate is a specialized developmental tissue containing characteristic
zonal arrangements of chondrocytes. The proliferative and differentiative states of …