Augmented efficiency of azithromycin for MRSA ocular infections management: Limonene-based nanostructured lipid carriers in-situ approach

KK Abla, SM Hijazi, MM Mehanna - Journal of Drug Delivery Science and …, 2023 - Elsevier
Staphylococcus aureus (S. aureus) is the main pathogen that leads to serious ocular
infectious disorders such as endophthalmitis and keratitis. A major obstacle in managing …

Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for ulcerative colitis

WA El-Dakroury, MB Zewail, GF Asaad… - European Journal of …, 2024 - Elsevier
The targeting and mucoadhesive features of chitosan (CS)-linked solid lipid nanoparticles
(SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a …

Docetaxel loaded in copaiba oil-nanostructured lipid carriers as a promising DDS for breast cancer treatment

FV Carvalho, LNM Ribeiro, LD Moura… - Molecules, 2022 - mdpi.com
Breast cancer is the neoplasia of highest incidence in women worldwide. Docetaxel (DTX), a
taxoid used to treat breast cancer, is a BCS-class-IV compound (low oral bioavailability …

Assessing the in vitro and in vivo performance of L-carnitine-loaded nanoparticles in combating obesity

B Uner, AD Ergin, IA Ansari, MS Macit-Celebi… - Molecules, 2023 - mdpi.com
Addressing obesity is a critical health concern of the century, necessitating urgent attention.
L-carnitine (LC), an essential water-soluble compound, plays a pivotal role in lipid …

Lipid nanoparticles based on natural matrices with activity against multidrug resistant bacterial species

EF da Silva, LM Bastos, BB Fonseca… - Frontiers in Cellular …, 2024 - frontiersin.org
Lately, the bacterial multidrug resistance has been a reason to public health concerning
around world. The development of new pharmacology therapies against infections caused …

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

MT Talianu, CE Dinu-Pîrvu, MV Ghica, V Anuţa… - Pharmaceutics, 2024 - mdpi.com
This research aimed to develop miconazole-based microemulsions using oleic acid as a
natural lipophilic phase and a stabilizer mixture comprising Tween 20 and PEG 400 to …

Mucoadhesive, thermoreversible hydrogel, containing tetracaine-loaded nanostructured lipid carriers for topical, intranasal needle-free anesthesia

GMF Calixto, BV Muniz, SR Castro, JSM de Araujo… - Pharmaceutics, 2021 - mdpi.com
Recent advances have been reported for needle-free local anesthesia in maxillary teeth by
administering a nasal spray of tetracaine (TTC) and oxymetazoline, without causing pain …

Development of a Versatile Nanostructured Lipid Carrier (NLC) Using Design of Experiments (DoE)—Part II: Incorporation and Stability of Butamben with Different …

AP Matarazzo, CA Rios, G Gerônimo, R Ondei… - Pharmaceutics, 2024 - mdpi.com
Nanostructured lipid carriers (NLCs) are typically composed of liquid lipids, solid lipids, and
surfactants, enabling the encapsulation of lipophilic drugs. Butamben is a Class II anesthetic …

Fresh Carrier for an Old Topical Local Anesthetic: Benzocaine in Nanostructured Lipid Carriers

AD Souza, GH Rodrigues da Silva… - ACS Biomaterials …, 2024 - ACS Publications
Nanostructured lipid carriers (NLC) have emerged as innovative drug delivery systems,
offering distinct advantages over other lipid-based carriers, such as liposomes and solid …

[HTML][HTML] Preformulation studies: a versatile tool in formulation design

K Ahirwar, R Shukla - Drug Formulation Design, 2023 - intechopen.com
The physicochemical properties of pharmacological molecules have a tremendous effect on
safety and efficacy. Poor physicochemical properties can often make it hard to set up a …