Translation of noncoding RNAs and cancer

B Zhou, H Yang, C Yang, Y Bao, S Yang, J Liu, Y Xiao - Cancer letters, 2021 - Elsevier
The human genome contains thousands of noncoding RNAs (ncRNAs), which are thought to
lack open reading frames (ORFs) and cannot be translated. Some ncRNAs reportedly have …

When long noncoding becomes protein coding

CCR Hartford, A Lal - Molecular and cellular biology, 2020 - Taylor & Francis
Recent advancements in genetic and proteomic technologies have revealed that more of the
genome encodes proteins than originally thought possible. Specifically, some putative long …

Micropeptide CIP 2A‐BP encoded by LINC 00665 inhibits triple‐negative breast cancer progression

B Guo, S Wu, X Zhu, L Zhang, J Deng, F Li… - The EMBO …, 2020 - embopress.org
TGF‐β signaling pathway plays a key role in breast cancer metastasis. Recent studies
suggest that TGF‐β regulates tumor progression and invasion not only via transcriptional …

Revisiting sORFs: overcoming challenges to identify and characterize functional microproteins

D Schlesinger, SJ Elsässer - The FEBS journal, 2022 - Wiley Online Library
Short ORFs (sORFs), that is, occurrences of a start and stop codon within 100 codons or
less, can be found in organisms of all domains of life, outnumbering annotated protein …

Landscape of noncoding RNA in prostate cancer

JT Hua, S Chen, HH He - Trends in Genetics, 2019 - cell.com
The transcriptome of prostate cancer is highly heterogeneous, with noncoding transcripts
being essential players. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are …

A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

XL Li, L Pongor, W Tang, S Das, BR Muys, MF Jones… - Elife, 2020 - elifesciences.org
Long noncoding RNAs (lncRNAs) are often associated with polysomes, indicating coding
potential. However, only a handful of endogenous proteins encoded by putative lncRNAs …

Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5/p300 complex

W Lv, W Jiang, H Luo, Q Tong, X Niu, X Liu… - Nucleic Acids …, 2022 - academic.oup.com
Long noncoding RNAs (lncRNAs) play important roles in the spatial and temporal regulation
of muscle development and regeneration. Nevertheless, the determination of their biological …

MiR-16-5p targets SESN1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation

B Cai, M Ma, B Chen, Z Li, BA Abdalla, Q Nie… - Cell death & …, 2018 - nature.com
The proliferation, apoptosis, and differentiation of myoblasts are essential processes in
skeletal muscle development. During this developmental process, microRNAs (miRNAs) …

Cancer-related micropeptides encoded by ncRNAs: Promising drug targets and prognostic biomarkers

S Setrerrahmane, M Li, A Zoghbi, X Lv, S Zhang… - Cancer letters, 2022 - Elsevier
An exciting emerging topic in the noncoding RNA (ncRNA) field is the discovery of short
peptides called micropeptides (≤ 100 amino acids), whose novel therapeutic opportunities …

MiPepid: MicroPeptide identification tool using machine learning

M Zhu, M Gribskov - BMC bioinformatics, 2019 - Springer
Background Micropeptides are small proteins with length<= 100 amino acids. Short open
reading frames that could produces micropeptides were traditionally ignored due to …