Hemoglobin-based oxygen carriers
CP Stowell - Current opinion in hematology, 2002 - journals.lww.com
Three types of materials have been studied as candidate blood substitutes: the
perfluorocarbons, modified hemoglobins, and liposome-encapsulated hemoglobin …
perfluorocarbons, modified hemoglobins, and liposome-encapsulated hemoglobin …
A phase I study of oxidized raffinose cross-linked human hemoglobin
FJL Carmichael, ACY Ali, JA Campbell… - Critical care …, 2000 - journals.lww.com
A phase I study of oxidized raffinose cross-linked human hem... : Critical Care Medicine A
phase I study of oxidized raffinose cross-linked human hemoglobin : Critical Care Medicine …
phase I study of oxidized raffinose cross-linked human hemoglobin : Critical Care Medicine …
Heme oxygenase-2 knockout neurons are less vulnerable to hemoglobin toxicity
B Rogers, V Yakopson, ZP Teng, Y Guo… - Free Radical Biology and …, 2003 - Elsevier
When cortical neurons are exposed to hemoglobin, they undergo oxidative stress that
ultimately results in iron-dependent cell death. Heme oxygenase (HO)-2 is constitutively …
ultimately results in iron-dependent cell death. Heme oxygenase (HO)-2 is constitutively …
[HTML][HTML] A phase II dose-response study of hemoglobin raffimer (Hemolink) in elective coronary artery bypass surgery
DCH Cheng, CD Mazer, R Martineau… - The Journal of Thoracic …, 2004 - Elsevier
BACKGROUND: We performed this study to determine the dose-response of hemoglobin
raffimer administered in conjunction with intraoperative autologous donation in patients …
raffimer administered in conjunction with intraoperative autologous donation in patients …
A recombinant polymeric hemoglobin with conformational, functional, and physiological characteristics of an in vivo O2 transporter
KM Bobofchak, T Mito, SJ Texel… - American Journal …, 2003 - journals.physiology.org
With the objective of developing a recombinant oxygen carrier suitable for therapeutic
applications, we have employed an Escherichia coli expression system to synthesize in high …
applications, we have employed an Escherichia coli expression system to synthesize in high …
Delayed treatment of hemoglobin neurotoxicity
RF Regan, B Rogers - Journal of neurotrauma, 2003 - liebertpub.com
Hemoglobin is an oxidative neurotoxin that may contribute to cell injury after CNS trauma
and hemorrhagic stroke. Prior studies have demonstrated that concomitant treatment with …
and hemorrhagic stroke. Prior studies have demonstrated that concomitant treatment with …
What happened to blood substitutes?
CP Stowell - Transfusion clinique et biologique, 2005 - Elsevier
Concerns about the safety and adequacy of the blood supply have fostered twenty years of
research into the so-called “blood substitutes” among them the oxygen carriers based on …
research into the so-called “blood substitutes” among them the oxygen carriers based on …
O‐raffinose crosslinked hemoglobin lacks site‐specific chemistry in the central cavity: Structural and functional consequences of β93Cys modification
RA Boykins, PW Buehler, Y Jia… - Proteins: Structure …, 2005 - Wiley Online Library
Reacting human deoxyHbA0 with oxidized raffinose (O‐raffinose), a trisaccharide, results in
a low oxygen affinity “blood substitute,” stabilized in a noncooperative T‐conformation and …
a low oxygen affinity “blood substitute,” stabilized in a noncooperative T‐conformation and …
Oxidized mono‐, di‐, tri‐, and polysaccharides as potential hemoglobin cross‐linking reagents for the synthesis of high oxygen affinity artificial blood substitutes
JH Eike, AF Palmer - Biotechnology progress, 2004 - Wiley Online Library
Various oxidized mono/di/tri/poly saccharides were studied as potential hemoglobin (Hb)
cross‐linkers in order to produce oxygen carriers with high oxygen affinities (low P50apos; …
cross‐linkers in order to produce oxygen carriers with high oxygen affinities (low P50apos; …
Clinical results of the application of perftoran for the treatment of odontogenous abcesses and phlegmons in the maxillofacial region
EA Durnovo, IV Furman, SY Pushkin… - Journal of Cranio …, 2008 - Elsevier
INTRODUCTION: The study was carried out to ascertain the effects of perftoran in the
treatment of facial and Dupuytren's phlegmons with simultaneous estimation of the general …
treatment of facial and Dupuytren's phlegmons with simultaneous estimation of the general …