Dostarlimab (JEMPERLI) is a PD-1 monoclonal antibody for the treatment of adult patients,
with mismatch repair deficient (dMMR), recurrent or advanced endometrial cancer that has …

The old Greek aphorism 'Panta Rhei'('everything flows') is true for all living things in general.
As a dynamic process, calcium signaling plays fundamental roles in cellular activities under …

Exosomes are small membrane vesicles containing microRNA, RNA, DNA fragments, and
proteins that are transferred from donor cells to recipient cells. Tumor cells release …

The study of molecular mechanisms at the single-cell level holds immense potential for
enhancing immunotherapy and understanding neuroinflammation and neurodegenerative …

LAG-3 (Lymphocyte activation gene 3) protein is a checkpoint receptor that interacts with
LSEC-tin, Galectin-3 and FGL1. This interaction leads to reduced production of IL-2 and IFN …

Objective Dostarlimab, a humanized monoclonal PD-1 blocking antibody, is being tested as
a cancer therapy in this review. Specifically, it addresses mismatch repair failure in …

Immunotherapies are a major breakthrough in oncology, yielding unprecedented response
rates for some cancers. Especially in combination with conventional treatments or targeted …

ABSTRACT Introduction The Ca2+ signaling toolkit is currently under investigation as a
potential target for addressing the threat of cancer. A growing body of evidence suggests …

Engineering and computational advances have opened many new avenues in cancer
research, particularly when being exploited in interdisciplinary approaches. For example …

Intercellular interaction between cell–cell and cell–ECM is critical to numerous biology and
medical studies, such as stem cell differentiation, immunotherapy and tissue engineering …