The myoD gene converts many differentiated cell types into muscle. MyoD is a member of
the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is …

Introduction 3. Development and determination of the myogenic lineage 3.1. Somitogenesis:
formation of epaxial versus hypaxial musculature 3.2. The myogenic regulatory factors 3.2 …

Mice carrying null mutations in the myogenic regulatory factors Myf-5 or YyoD have
apparently normal skeletal muscle. To address whether these two factors functionally …

The myogenic basic HLH transcription factor family of genes, composed of MyoD, myogenin,
Myf-5, and Myf-6, are thought to regulate skeletal muscle differentiation. To understand the …

We have studied the initial development of pluripotent gut endoderm to hepatocytes using a
tissue explant system from mouse embryos. We not only find cellular interactions that specify …

The Myf-5 gene, a member of the myogenic basic HLH factor family, has been inactivated in
mice after homologous recombination in ES cells. Mice lacking Myf-5 were unable to …

We have analysed by in situ hybridization the expression of myf-5, the murine homologue of
the human myogenic regulatory sequence myf5, during embryogenesis in the mouse, myf-5 …

In this report we provide four lines of evidence indicating that El2/E47-like proteins interact in
vivo with the myogenic HLH proteins MyoDand myogenin. First, cotransfection of MyoD and …

DrosophiIa and Caenorhabditis elegans, however, the mechanisms that establish complex
cellular phenotypes in vertebrates have been more difficult to approach. The recent …

Inflammation and tissue regeneration follow tissue damage, but little is known about how
these processes are coordinated. High Mobility Group Box 1 (HMGB1) is a nuclear protein …