TonB-dependent transporters (TBDTs) are bacterial outer membrane proteins that bind and
transport ferric chelates, called siderophores, as well as vitamin B12, nickel complexes, and …

Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Bacteria are able to survive in low-iron environments by sequestering this metal ion from
iron-containing proteins and other biomolecules such as transferrin, lactoferrin, heme …

Porphyromonas gingivalis, a main etiologic agent and key pathogen responsible for
initiation and progression of chronic periodontitis requires heme as a source of iron and …

Iron is essential for the survival of most bacteria but presents a significant challenge given its
limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain …

Pseudomonas aeruginosa PAO1 encodes two outer membrane receptors, PhuR
(Pseudomonas heme uptake) and HasR (heme assimilation system). The HasR and PhuR …

Vitamin B12 (or cobalamin) is an enzymatic cofactor essential both for mammals and
bacteria. However, cobalamin can be synthesized only by few microorganisms so most …

A repertoire of transporters plays a crucial role in maintaining homeostasis of biologically
essential transition metals, manganese, and iron, thus ensuring cell viability. Elucidating the …

The periplasmic binding protein HmuT from Yersinia pestis (YpHmuT) is a component of the
heme uptake locus hmu and delivers bound hemin to the inner-membrane-localized, ATP …

We studied the Escherichia coli outer membrane protein Fiu, a presumed transporter of
monomeric ferric catecholates, by introducing Cys residues in its surface loops and …