Highlights•In-depth sequence analysis reveals that the protein fold universe is more
evolutionarily connected than previously assumed.•Short ancestral fragments are observed …

The protein design problem is to identify an amino acid sequence that folds to a desired
structure. Given Anfinsen's thermodynamic hypothesis of folding, this can be recast as …

The enzyme soybean lipoxygenase (SLO) provides a prototype for deep tunneling
mechanisms in hydrogen transfer catalysis. This work combines room temperature X-ray …

A well-known method for reducing or swapping out undesirable and controversial fats in
food is oleogelation. To quantify the effects of droplets-particle inclusion on the textural …

Proteins of thermophiles are thermally stable in a high‐temperature environment, adopting a
strategy of enhancing the electrostatic interaction in hydrophobic media at high temperature …

The experimental characterization and computational prediction of protein structures has
become increasingly rapid and precise. However, the analysis of protein structures often …

Transition paths comprise those parts of a folding trajectory where the molecule passes
through the high-energy transition states separating folded and unfolded conformations. The …

Formate dehydrogenase can be utilized as a biocatalyst in the bioelectrocatalysis of
converting CO2 into formic acid. However, its industrial application has been hindered by …

Over the past decades, there has been a flourishing of phase-separated polymer gels.
Unlike traditional design methods that rely on chemical structure and polymer network …

The ability to design stable proteins with custom-made functions is a major goal in
biochemistry with practical relevance for our environment and society. Understanding and …