Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
T Nojima, NJ Proudfoot - Nature reviews Molecular cell biology, 2022 - nature.com
Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
Cellular functions of long noncoding RNAs
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …
are transcribed from the mammalian genome. They are emerging as important regulators in …
Determinants of enhancer and promoter activities of regulatory elements
R Andersson, A Sandelin - Nature Reviews Genetics, 2020 - nature.com
The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …
transcription within a cell. Although diverse methodologies have been developed to identify …
Eukaryotic core promoters and the functional basis of transcription initiation
Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …
transcription start sites of protein-coding and non-coding genes that support the assembly of …
History, discovery, and classification of lncRNAs
J Jarroux, A Morillon, M Pinskaya - Long non coding RNA biology, 2017 - Springer
Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
Linking long noncoding RNA localization and function
LL Chen - Trends in biochemical sciences, 2016 - cell.com
Recent studies have revealed the regulatory potential of many long noncoding RNAs
(lncRNAs). Most lncRNAs, like mRNAs, are transcribed by RNA polymerase II and are …
(lncRNAs). Most lncRNAs, like mRNAs, are transcribed by RNA polymerase II and are …
The Landscape of long noncoding RNA classification
GS Laurent, C Wahlestedt, P Kapranov - Trends in genetics, 2015 - cell.com
Advances in the depth and quality of transcriptome sequencing have revealed many new
classes of long noncoding RNAs (lncRNAs). lncRNA classification has mushroomed to …
classes of long noncoding RNAs (lncRNAs). lncRNA classification has mushroomed to …
Enhancers as non-coding RNA transcription units: recent insights and future perspectives
Networks of regulatory enhancers dictate distinct cell identities and cellular responses to
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …
An atlas of active enhancers across human cell types and tissues
Enhancers control the correct temporal and cell-type-specific activation of gene expression
in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial …
in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial …
[HTML][HTML] U1 snRNP regulates cancer cell migration and invasion in vitro
Stimulated cells and cancer cells have widespread shortening of mRNA 3'-untranslated
regions (3'UTRs) and switches to shorter mRNA isoforms due to usage of more proximal …
regions (3'UTRs) and switches to shorter mRNA isoforms due to usage of more proximal …