Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

A plethora of applications using polysaccharides have been developed in recent years due
to their availability as well as their frequent nontoxicity and biodegradability. These polymers …

Chondroitin sulfate (CS) is a naturally derived bioactive macromolecule and the major
component of extracellular matrix (ECM), which widely distributed in various organisms and …

Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to
promote bone formation in fracture nonunions, large bone defects, and spinal fusion …

Activated microglia/macrophages infiltration, astrocyte migration, and increased production
of inhibitory chondroitin sulfate proteoglycans (CSPGs) are standard harmful events taking …

In addition to neuroprotective strategies, neuroregenerative processes could provide targets
for stroke recovery. However, the upregulation of inhibitory chondroitin sulfate proteoglycans …

Although biomimetic hydrogels play an essential role in guiding bone remodeling,
reconstructing large bone defects is still a significant challenge since bioinspired gels often …

Stroke is the second leading cause of death worldwide and has two major subtypes:
ischemic stroke and hemorrhagic stroke. Neuroinflammation is a pathological hallmark of …

Many studies, using pre-clinical models of SCI, have demonstrated the efficacy of
chondroitinase ABC as a treatment for spinal cord injury and this has been confirmed in …

Therapeutic proteins can treat a myriad of diseases; however, their effectiveness is limited
by short half-lives. Controlled release systems are advantageous because they prolong the …