Aberrant function of cell cycle regulators results in uncontrolled cell proliferation, making
them attractive therapeutic targets in cancer treatment. Indeed, survival of many cancers …

p62/SQSTM 1 is a multifunctional signaling hub and autophagy adaptor with many binding
partners, which allow it to activate mTORC 1‐dependent nutrient sensing, NF‐κB‐mediated …

Keloids exhibit metabolic reprogramming including enhanced glycolysis and attenuated
oxidative phosphorylation. Hypoxia induces a series of protective responses in mammalian …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

ABSTRACT SCAP (SREBF chaperone) regulates SREBFs (sterol regulatory element
binding transcription factors) processing and stability, and, thus, becomes an emerging drug …

Abstract Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the
transportation, degradation and destruction of various proteins that cooperates with …

Abstract p62 is an important multifunctional adaptor protein participating in autophagy and
many other activities. Many studies have revealed that p62 is highly expressed in multiple …

Platinum‐based therapeutic strategies have been widely used in ovarian cancer treatment.
However, drug resistance has greatly limited therapeutic efficacy. Recently, tolerance to …

Background Glioma is the most common central nervous system (CNS) tumour. p62, an
important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the …

Mutations in Kelch-like ECH-associated protein 1 (KEAP1) cause the aberrant activation of
nuclear factor erythroid-derived 2-like 2 (NRF2), which leads to oncogenesis and drug …