Tissue factor (TF) is the high-affinity receptor and cofactor for factor (F) VII/VIIa. The TF-FVIIa
complex is the primary initiator of blood coagulation and plays an essential role in …

The plasma coagulation system in mammalian blood consists of a cascade of enzyme
activation events in which serine proteases activate the proteins (proenzymes and …

Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …

Clinical and epidemiological studies support a connection between obesity and thrombosis,
involving elevated expression of the prothrombotic molecules plasminogen activator …

Expanding evidence indicates multiple interactions between the hemostatic system and
innate immunity, and the coagulation and complement cascades. Here we show in a tissue …

Sepsis is a serious clinical condition that represents a patient's response to a severe
infection and has a very high mortality rate. Normal immune and physiologic responses …

Thrombosis, or blood clot formation, and its sequelae remain a leading cause of morbidity
and mortality, and recurrent thrombosis is common despite current optimal therapy. Protein …

Protease-activated receptors (PARs) are G protein-coupled receptors that are activated by
proteolytical cleavage of the amino-terminus and thereby act as sensors for extracellular …

The tissue factor (TF) pathway plays a central role in hemostasis and thrombo‐inflammatory
diseases. Although structure‐function relationships of the TF initiation complex are …