Botulinum neurotoxins: biology, pharmacology, and toxicology
M Pirazzini, O Rossetto, R Eleopra… - Pharmacological …, 2017 - ASPET
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
Botulism
EA Johnson, C Montecucco - Handbook of clinical neurology, 2008 - Elsevier
Publisher Summary Botulism is an acute neuroparalytic disease of humans and animals
caused through the action of botulinum neurotoxins (BoNTs) acting at the neuromuscular …
caused through the action of botulinum neurotoxins (BoNTs) acting at the neuromuscular …
A novel botulinum neurotoxin, previously reported as serotype H, has a hybrid-like structure with regions of similarity to the structures of serotypes A and F and is …
SE Maslanka, C Lúquez, JK Dykes… - The Journal of …, 2016 - academic.oup.com
Botulism is a potentially fatal paralytic disease caused by the action of botulinum neurotoxin
(BoNT) on nerve cells. There are 7 known serotypes (A–G) of BoNT and up to 40 genetic …
(BoNT) on nerve cells. There are 7 known serotypes (A–G) of BoNT and up to 40 genetic …
Characterization of Botulinum Neurotoxin A Subtypes 1 Through 5 by Investigation of Activities in Mice, in Neuronal Cell Cultures, and In Vitro
RCM Whitemarsh, WH Tepp, M Bradshaw… - Infection and …, 2013 - Am Soc Microbiol
Botulinum neurotoxins (BoNTs) are synthesized by Clostridium botulinum and exist as
seven immunologically distinct serotypes designated A through G. For most serotypes …
seven immunologically distinct serotypes designated A through G. For most serotypes …
Novel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detection
RCM Whitemarsh, MJ Strathman… - Toxicological …, 2012 - academic.oup.com
Human induced pluripotent stem cells (hiPSC) hold great promise for providing various
differentiated cell models for in vitro toxigenicity testing. For Clostridium botulinum …
differentiated cell models for in vitro toxigenicity testing. For Clostridium botulinum …
Progress in cell based assays for botulinum neurotoxin detection
S Pellett - Botulinum neurotoxins, 2013 - Springer
Botulinum neurotoxins (BoNTs) are the most potent human toxins known and the causative
agent of botulism, and are widely used as valuable pharmaceuticals. The BoNTs are …
agent of botulism, and are widely used as valuable pharmaceuticals. The BoNTs are …
Persistence of botulinum neurotoxin a subtypes 1-5 in primary rat spinal cord cells
RCM Whitemarsh, WH Tepp, EA Johnson, S Pellett - PLoS one, 2014 - journals.plos.org
Botulinum neurotoxins (BoNTs) are the most poisonous substances known and cause the
severe disease botulism. BoNTs have also been remarkably effective as therapeutics in …
severe disease botulism. BoNTs have also been remarkably effective as therapeutics in …
The light chain defines the duration of action of botulinum toxin serotype A subtypes
S Pellett, M Bradshaw, WH Tepp, CL Pier… - MBio, 2018 - Am Soc Microbiol
Botulinum neurotoxin (BoNT) is the causative agent of botulism and a widely used
pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins …
pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins …
[HTML][HTML] Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1
CL Pier, C Chen, WH Tepp, G Lin, KD Janda… - FEBS letters, 2011 - Elsevier
Botulinum neurotoxins (BoNTs), the causative agent of human botulism, are the most potent
naturally occurring toxins known. BoNT/A1, the most studied BoNT, is also used as an …
naturally occurring toxins known. BoNT/A1, the most studied BoNT, is also used as an …
Bimodal modulation of the botulinum neurotoxin protein-conducting channel
A Fischer, Y Nakai, LM Eubanks… - Proceedings of the …, 2009 - National Acad Sciences
Clostridium botulinum neurotoxin (BoNT) is the causative agent of botulism, a neuroparalytic
disease. We describe here a semisynthetic strategy to identify inhibitors based on …
disease. We describe here a semisynthetic strategy to identify inhibitors based on …