Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …

Podocyte injury is a major determinant of proteinuric kidney disease and the identification of
potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we …

The recent discoveries in the fields of pathogenesis and management of diabetic
nephropathy have revolutionized the knowledge about this disease. Little was added to the …

Renal activation of the complement system has been described in patients with diabetic
nephropathy (DN), although its pathological relevance is still ill-defined. Here, we studied …

Diabetes mellitus and hypertension are major risk factors for chronic kidney injury, together
accounting for> 70% of end-stage renal disease. In this study, we assessed interactions of …

A number of investigations have addressed the importance of high glucose in breast cancer,
however, the involvement of angiotensinogen (AGT) in this scenario is yet to be defined …

Context: Renal disease in type 2 diabetes mellitus (T2DM) is associated with excess
morbidity/mortality. Although estimated glomerular filtration rate (eGFR) and albuminuria are …

Generating human podocytes in vitro could offer a unique opportunity to study human
diseases. Here, we describe a simple and efficient protocol for obtaining functional …

Diabetic nephropathy (DN), characterized by glomerular injury, is a common complication of
both type 1 and type 2 diabetes, accompanied by massive proteinuria. Podocytes are …

Rationale: Recent studies have demonstrated that the loss of podocyte is a critical event in
diabetic nephropathy (DN). Previously, our group have found that the mitotic arrest deficient …