Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

Introduction: For half a century, a high level of total cholesterol (TC) or low-density
lipoprotein cholesterol (LDL-C) has been considered to be the major cause of …

Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism
characterized by very high plasma concentrations of low density lipoprotein cholesterol …

Atherosclerotic coronary artery disease (CAD) comprises a broad spectrum of clinical
entities that include asymptomatic subclinical atherosclerosis and its clinical complications …

Approximately 50 mutations and many single nucleotide polymorphisms have been
described in the ABCA1 gene, with mutations leading to Tangier disease and familial …

Familial hypercholesterolemia (FH) is a common genetic cause of elevated low-density
lipoprotein cholesterol (LDL-C) due to defective clearance of circulating LDL particles. All FH …

▪ Abstract Cholesterol and its metabolites play a variety of essential roles in living systems.
Virtually all animal cells require cholesterol, which they acquire through synthesis or uptake …

Homozygotes for loss-of-function mutations in ABCA1 cause Tangier disease. The
phenotype of their markedly reduced or loss of blood high-density lipoprotein (HDL) …

The ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound exporter protein
involved in regulating serum HDL level by exporting cholesterol and phospholipids to load …

Background: We aimed to systematically examine literature on the prevalence of known
modifiable and nonmodifiable risk factors for premature coronary heart disease (PCHD) in …