Cardiac autonomic neuropathy: a progressive consequence of chronic low-grade inflammation in type 2 diabetes and related metabolic disorders

NMZ Bakkar, HS Dwaib, S Fares, AH Eid… - International journal of …, 2020 - mdpi.com
Cardiac autonomic neuropathy (CAN) is one of the earliest complications of type 2 diabetes
(T2D), presenting a silent cause of cardiovascular morbidity and mortality. Recent research …

Beat-to-beat blood pressure variability: an early predictor of disease and cardiovascular risk

NMZ Bakkar, AF El-Yazbi, FA Zouein… - Journal of …, 2021 - journals.lww.com
Blood pressure (BP) varies on the long, short and very-short term. Owing to the hidden
physiological and pathological information present in BP time-series, increasing interest has …

Hemodynamic responses to handgrip and metaboreflex activation are exaggerated in individuals with metabolic syndrome independent of resting blood pressure …

J Stavres, RA Aultman, CF Brandner… - Frontiers in …, 2023 - frontiersin.org
Introduction: Prior studies report conflicting evidence regarding exercise pressor and
metaboreflex responses in individuals with metabolic syndrome (MetS). Purpose: To test the …

Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs

SH Hammoud, I AlZaim, N Mougharbil, S Koubar… - Biochemical …, 2021 - Elsevier
Diabetic nephropathy is a major health challenge with considerable economic burden and
significant impact on patients' quality of life. Despite recent advances in diabetic patient care …

Modulatory effect of intermittent fasting on adipose tissue inflammation: amelioration of cardiovascular dysfunction in early metabolic impairment

HS Dwaib, I AlZaim, AH Eid, O Obeid… - Frontiers in …, 2021 - frontiersin.org
Cardiometabolic syndrome (CMS) is a cluster of maladaptive cardiovascular, renal,
thrombotic, inflammatory, and metabolic disorders. It confers a high risk of cardiovascular …

Phosphorus supplementation mitigates perivascular adipose inflammation–induced cardiovascular consequences in early metabolic impairment

HS Dwaib, G Ajouz, I AlZaim, R Rafeh… - Journal of the …, 2021 - Am Heart Assoc
Background The complexity of the interaction between metabolic dysfunction and
cardiovascular complications has long been recognized to extend beyond simple …

The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: Impact beyond reduced clotting

RA Alaaeddine, I AlZaim, SH Hammoud… - Clinical …, 2021 - portlandpress.com
Antithrombotic drugs are widely used for primary and secondary prevention, as well as
treatment of many cardiovascular disorders. Over the past few decades, major advances in …

Spontaneous baroreflex sensitivity is attenuated in male UCD-type 2 diabetes mellitus rats: A link between metabolic and autonomic dysfunction

M Samora, Y Huo, RK McCuller, S Chidurala… - Autonomic …, 2023 - Elsevier
Patients with type 2 diabetes mellitus (T2DM) have impaired arterial baroreflex function,
which may be linked to the co-existence of obesity. However, the role of obesity and its …

High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury

S Ibeh, NMZ Bakkar, F Ahmad, J Nwaiwu, C Barsa… - Life Sciences, 2023 - Elsevier
Aims Traumatic brain injury (TBI) constitutes a serious public health concern. Although TBI
targets the brain, it can exert several systemic effects which can worsen the complications …

Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

NMZ Bakkar, I AlZaim, AF El-Yazbi - Clinical Science, 2022 - portlandpress.com
Abstract Sodium-glucose transporter-2 inhibitors (SGLT-2i) and glucagon-like peptide 1
(GLP-1) receptor agonists are newer antidiabetic drug classes, which were recently shown …