Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions
In this study, a library of twelve beta-lactam-substituted benzenesulfonamides (5a–l) was
synthesized using the tail-approach method. The compounds were characterized using IR …
synthesized using the tail-approach method. The compounds were characterized using IR …
PET radiotracers and fluorescent probes for imaging human carbonic anhydrase IX and XII in hypoxic tumors
Positron emission tomography (PET) and fluorescent imaging play a pivotal role in medical
diagnosis, biomedical oncologic research, and drug development process, which include …
diagnosis, biomedical oncologic research, and drug development process, which include …
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect
J Ivanova, A Nocentini, K Tars, J Leita̅ns… - Journal of Medicinal …, 2023 - ACS Publications
Here, we report for the first time a series of sulfonamide derivatives with scaffolds bearing
flexible moieties, namely, rotamers or tropoisomers capable of adapting their geometry in …
flexible moieties, namely, rotamers or tropoisomers capable of adapting their geometry in …
Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the …
Hypoxia, a characteristic feature of solid tumors, develops as a result of excessive cell
proliferation and rapid tumor growth exceeding the oxygen supply, and can result in …
proliferation and rapid tumor growth exceeding the oxygen supply, and can result in …
Terminators or guardians? design, synthesis, and cytotoxicity profiling of chalcone-sulfonamide hybrids
With a “less is more” philosophy, a series of 15 chalcone-sulfonamide hybrids were
designed anticipating synergistic anticancer activity. The aromatic sulfonamide moiety was …
designed anticipating synergistic anticancer activity. The aromatic sulfonamide moiety was …
Benzenesulfonamides with different rigidity-conferring linkers as carbonic anhydrase inhibitors: an insight into the antiproliferative effect on glioblastoma, pancreatic …
Among the chemotypes studied for selective inhibition of tumour-associated carbonic
anhydrases (CAs), SLC-0111, a ureido-bearing benzenesulfonamide CA IX inhibitor …
anhydrases (CAs), SLC-0111, a ureido-bearing benzenesulfonamide CA IX inhibitor …
4-(3-Alkyl/benzyl-guanidino) benzenesulfonamides as selective carbonic anhydrase VII inhibitors
The treatment of chronic neuropathic pain remains one of the most challenging of all
neurological diseases and very much an art. There exists no consensus for the optimal …
neurological diseases and very much an art. There exists no consensus for the optimal …
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In …
SM Hefny, TF El-Moselhy, N El-Din… - Journal of Medicinal …, 2024 - ACS Publications
A dual-targeting approach is predicted to yield better cancer therapy outcomes.
Consequently, a series of coumarin-based thiazoles (5a–h, 6, and 7a–e) were designed and …
Consequently, a series of coumarin-based thiazoles (5a–h, 6, and 7a–e) were designed and …
Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents
Herein we reported the design and synthesis of two series comprising twenty-two
benzenesulfonamides that integrate the s-triazine moiety. Target compounds successfully …
benzenesulfonamides that integrate the s-triazine moiety. Target compounds successfully …