To compare findings across species, neuroscience relies on cross-species homologies,
particularly in terms of brain areas. For cingulate cortex, a structure implicated in behavioural …

The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …

Oxytocin is a well-known neurohypophysial hormone that plays an important role in
behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic …

Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive,
and affective symptoms. Over the past 2 decades, researchers have made significant …

While depression and chronic pain are frequently comorbid, underlying neuronal circuits
and their psychopathological relevance remain poorly defined. Here we show in mice that …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Over the past 20 years, clinical and preclinical studies point to the anterior cingulate cortex
(ACC) as a site of interest for several neurological and psychiatric conditions. The ACC …

The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in the
central nervous system and is involved intensively in modulating pain and stress-related …

The primary objective of preclinical pain research is to improve the treatment of pain.
Decades of research using pain-evoked tests has revealed much about mechanisms but …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …