Where is cingulate cortex? A cross-species view
S van Heukelum, RB Mars, M Guthrie… - Trends in …, 2020 - cell.com
To compare findings across species, neuroscience relies on cross-species homologies,
particularly in terms of brain areas. For cingulate cortex, a structure implicated in behavioural …
particularly in terms of brain areas. For cingulate cortex, a structure implicated in behavioural …
Neocortical circuits in pain and pain relief
LL Tan, R Kuner - Nature Reviews Neuroscience, 2021 - nature.com
The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …
incoming noxious inputs to generate variable pain perceptions. Technological advances in …
Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation
XH Li, T Matsuura, M Xue, QY Chen, RH Liu, JS Lu… - Cell reports, 2021 - cell.com
Oxytocin is a well-known neurohypophysial hormone that plays an important role in
behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic …
behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic …
The mesolimbic dopamine system in chronic pain and associated affective comorbidities
RA Serafini, KD Pryce, V Zachariou - Biological psychiatry, 2020 - Elsevier
Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive,
and affective symptoms. Over the past 2 decades, researchers have made significant …
and affective symptoms. Over the past 2 decades, researchers have made significant …
The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice
LJ Becker, C Fillinger, R Waegaert, SH Journée… - Nature …, 2023 - nature.com
While depression and chronic pain are frequently comorbid, underlying neuronal circuits
and their psychopathological relevance remain poorly defined. Here we show in mice that …
and their psychopathological relevance remain poorly defined. Here we show in mice that …
How to study anxiety and depression in rodent models of chronic pain?
Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …
suffering from chronic pain. Over time, different tests and models have been developed in …
Janus effect of the anterior cingulate cortex: Pain and emotion
SH Journée, VP Mathis, C Fillinger, P Veinante… - Neuroscience & …, 2023 - Elsevier
Over the past 20 years, clinical and preclinical studies point to the anterior cingulate cortex
(ACC) as a site of interest for several neurological and psychiatric conditions. The ACC …
(ACC) as a site of interest for several neurological and psychiatric conditions. The ACC …
[HTML][HTML] The role of the locus coeruleus in pain and associated stress-related disorders
I Suárez-Pereira, M Llorca-Torralba, L Bravo… - Biological …, 2022 - Elsevier
The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in the
central nervous system and is involved intensively in modulating pain and stress-related …
central nervous system and is involved intensively in modulating pain and stress-related …
Pros and cons of clinically relevant methods to assess pain in rodents
The primary objective of preclinical pain research is to improve the treatment of pain.
Decades of research using pain-evoked tests has revealed much about mechanisms but …
Decades of research using pain-evoked tests has revealed much about mechanisms but …
Animal models of pain: diversity and benefits
C Abboud, A Duveau, R Bouali-Benazzouz… - Journal of neuroscience …, 2021 - Elsevier
Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …