Caffeic acid phenethyl ester as a protective agent against nephrotoxicity and/or oxidative kidney damage: a detailed systematic review

S Akyol, V Ugurcu, A Altuntas, R Hasgul… - The Scientific World …, 2014 - Wiley Online Library
Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting
the attention of different medical and pharmaceutical disciplines in recent years because of …

A systematic meta-analysis on the efficacy of pre-clinically tested nephroprotectants at preventing aminoglycoside nephrotoxicity

L Vicente-Vicente, AG Casanova… - Toxicology, 2017 - Elsevier
Nephrotoxicity limits the use of aminoglycoside antibiotics. Kidney damage is produced
mainly in the renal tubule due to an inflammatory and oxidative process. At preclinical level …

Protective Effects of Caffeic Acid Phenethyl Ester, Vitamin C, Vitamin E and N‐Acetylcysteine on Vancomycin‐Induced Nephrotoxicity in Rats

S Ocak, S Gorur, S Hakverdi, S Celik… - Basic & clinical …, 2007 - Wiley Online Library
The objective of this study was to compare the beneficial effects of caffeic acid phenethyl
ester (CAPE), vitamin C, vitamin E and N‐acetylcysteine on vancomycin‐induced …

Caffeic acid phenethyl ester attenuates nuclear factor‑κB‑mediated inflammatory responses in Müller cells and protects against retinal ganglion cell death

Y Jia, S Jiang, C Chen, G Lu… - Molecular …, 2019 - spandidos-publications.com
Glaucoma is characterized by the death of retinal ganglion cells (RGCs) and visual field
defects, and is a leading cause of blindness worldwide. Caffeic acid phenethyl ester (CAPE) …

Thymoquinone protection from amikacin induced renal injury in rats

MK Ozer, S Bilgic, I Armagan… - Biotechnic & …, 2020 - Taylor & Francis
We investigated whether thymoquinone (TQ) exerts a beneficial effect on renal injury due to
amikacin (AK) administration in rats. To generate kidney damage with AK, a single 1.2 g/kg …

Antioxidative and Anti‐Inflammatory Protective Effects of β‐Caryophyllene against Amikacin‐Induced Nephrotoxicity in Rat by Regulating the Nrf2/AMPK/AKT and NF‐κB/TGF …

BS Rajab, TA Albukhari, AA Khan… - Oxidative Medicine …, 2022 - Wiley Online Library
Herein, the molecular pathogenic pathways implicated in renal injury triggered by amikacin
(AK), together with the alleviating actions of β‐caryophyllene (BCP), were investigated. Adult …

Prevention of nephrotoxicity induced by amikacin: The role of misoprostol, A prostaglandin E1 analogue

S Azırak - Prostaglandins & Other Lipid Mediators, 2023 - Elsevier
Amikacin (AK) is an aminoglycoside that is widely used to treat life-threatening Gram-
negative infections, especially in intensive care units. Despite its wide clinical indications …

Effects of pentoxifylline on amikacin-induced nephrotoxicity in rats

MK Ozer, H Asci, M Oncu, S Yesilot, M Savran… - Renal failure, 2009 - Taylor & Francis
The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model.
Rats were received a single injection of AK (1.2 g/kg, ip) with or without PTX pretreatment …

Evaluation of the possible nephroprotective effects of vitamin E and rosuvastatin in amikacin‐induced renal injury in rats

A Selim, MM Khalaf, AM Gad… - Journal of Biochemical …, 2017 - Wiley Online Library
Amikacin (AMIK) is an aminoglycoside antibiotic that possesses considerable nephrotoxic
adverse effects. This study examined the protective effects of vitamin E (VIT. E) or …

The effect of grape seed proanthocyanidin extract in preventing amikacin-induced nephropathy

S Ulusoy, G Ozkan, S Ersoz, A Orem, M Alkanat… - Renal failure, 2012 - Taylor & Francis
Background/Aims: Nephrotoxicity induced by aminoglycosides (AGs) limits their clinical use.
As yet, no molecules have been approved to prevent AG nephropathy. We aim to investigate …