Rotavirus vaccines have demonstrated impact in reducing diarrheal morbidity and mortality
worldwide. As countries begin to introduce the newly prequalified vaccines, additional data …

The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Background The past two decades have seen expansion of childhood vaccination
programmes in low-income and middle-income countries (LMICs). We quantify the health …

Rotavirus claims thousands of lives of children globally every year with a disproportionately
high burden in low-and lower-middle income countries where access to health care is …

Background A monovalent, parenteral, subunit rotavirus vaccine was well tolerated and
immunogenic in adults in the USA and in toddlers and infants in South Africa, but elicited …

In the decade since oral rotavirus vaccines (ORV) were recommended by the World Health
Organization for universal inclusion in all national immunization programs, significant yet …

Innate resistance to viral infections can be attributed to mutations in genes involved in the
immune response, or to the receptor/ligand. A remarkable example of the latter is the …

Background: The introduction of the rotavirus vaccine in Bayelsa State, Nigeria, aimed to
combat the high incidence of acute watery diarrhea and associated mortality in children …

Diarrhea is a leading cause of antibiotic consumption among children in low-and middle-
income countries. While vaccines may prevent diarrhea infections for which children often …

Rotavirus (RV) causes the loss of numerous children's lives worldwide each year, and this
burden is particularly heavy in low-and lower-middle-income countries where access to …