[HTML][HTML] Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets
Multiple studies suggested using different miRNAs as biomarkers for prognosis of
hepatocellular carcinoma (HCC). We aimed to assemble a miRNA expression database …
hepatocellular carcinoma (HCC). We aimed to assemble a miRNA expression database …
[HTML][HTML] HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer
EC de Heer, M Jalving, AL Harris - The Journal of clinical …, 2020 - Am Soc Clin Investig
Hypoxia-inducible factors (HIFs) and the HIF-dependent cancer hallmarks angiogenesis and
metabolic rewiring are well-established drivers of breast cancer aggressiveness, therapy …
metabolic rewiring are well-established drivers of breast cancer aggressiveness, therapy …
[HTML][HTML] Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer
B Győrffy - Computational and structural biotechnology journal, 2021 - Elsevier
Introduction Extensive research is directed to uncover new biomarkers capable to stratify
breast cancer patients into clinically relevant cohorts. However, the overall performance …
breast cancer patients into clinically relevant cohorts. However, the overall performance …
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a
small subset of these cells generates metastases. We conducted an in vivo genome-wide …
small subset of these cells generates metastases. We conducted an in vivo genome-wide …
[HTML][HTML] Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients
Results The entire database incorporates 1,065 gastric carcinoma samples, gene
expression data. Out of 29 established markers, higher expression of BECN1 (HR= 0.68, p …
expression data. Out of 29 established markers, higher expression of BECN1 (HR= 0.68, p …
Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers
We have profiled, for the first time, an evolving human metastatic microenvironment by
measuring gene expression, matrisome proteomics, cytokine and chemokine levels …
measuring gene expression, matrisome proteomics, cytokine and chemokine levels …
Kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer
Acquired resistance to cyclin-dependent kinases 4 and 6 (CDK4/6) small-molecule inhibitors
in breast cancer arises through mechanisms that are yet uncharacterized. In this study, we …
in breast cancer arises through mechanisms that are yet uncharacterized. In this study, we …
ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis
SJ Chung, GP Nagaraju, A Nagalingam, N Muniraj… - Autophagy, 2017 - Taylor & Francis
ABSTRACT ADIPOQ/adiponectin, an adipocytokine secreted by adipocytes in the breast
tumor microenvironment, negatively regulates cancer cell growth hence increased levels of …
tumor microenvironment, negatively regulates cancer cell growth hence increased levels of …
[HTML][HTML] Increased cholesterol biosynthesis is a key characteristic of breast cancer stem cells influencing patient outcome
S Ehmsen, MH Pedersen, G Wang, MG Terp… - Cell reports, 2019 - cell.com
Tumor eradication may be greatly improved by targeting cancer stem cells (CSCs), as they
exhibit resistance to conventional therapy. To gain insight into the unique biology of CSCs …
exhibit resistance to conventional therapy. To gain insight into the unique biology of CSCs …
miR‐34a is an intracellular and exosomal predictive biomarker for response to docetaxel with clinical relevance to prostate cancer progression
BACKGROUND Docetaxel‐resistance limits successful treatment of castration resistant
prostate cancer. We previously demonstrated that extracellular vesicles (exosomes) may …
prostate cancer. We previously demonstrated that extracellular vesicles (exosomes) may …