Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

Bursting is one of the fundamental rhythms that excitable cells can generate either in
response to incoming stimuli or intrinsically. It has been a topic of intense research in …

While phase reduction is a tremendously useful tool for understanding the dynamics of
weakly perturbed limit cycle oscillators, its assumptions break down as perturbations …

Using the FitzHugh-Nagumo equations to represent the oscillatory electrical behavior of β-
cells, we develop a coupled oscillator network model with cubic lattice topology, showing …

NMDA receptors promote repolarization in pancreatic beta cells and thereby reduce glucose-
stimulated insulin secretion. Therefore, NMDA receptors are a potential therapeutic target for …

The pancreas plays a critical role in maintaining glucose homeostasis through the secretion
of hormones from the islets of Langerhans. Glucose-stimulated insulin secretion (GSIS) by …

Glycolysis is the central metabolic pathway of almost every cell and organism. Under
appropriate conditions, glycolytic oscillations may occur in individual cells as well as in …

The accurate regulation of glucose within humans is an essential feature of homeostasis. It
optimises energy release in the muscles and organs. Glucose rhythms driven by internal …

Temporal order in living matters reflects the self-organizing nature of dynamical processes
driven out of thermodynamic equilibrium. Because of functional reasons, the period of a …

Abstract Type 2 diabetes (T2D) is a global health problem caused primarily due to the
inability of pancreatic beta-cells to secrete adequate amounts of insulin during insulin …