Induced pluripotent stem cells (iPSCs) offer great promise in the areas of disease modeling,
basic research, drug development, and regenerative medicine. Much of their value comes …

Primary cilia are crucial for normal cardiac organogenesis via the formation of cyto-
architectural, anatomical, and physiological boundaries in the developing heart and outflow …

The ability to accurately phenotype cells differentiated from human induced pluripotent stem
cells (hiPSCs) is essential for their application in modeling developmental and disease …

Characterizing the contractile function of human pluripotent stem cell-derived
cardiomyocytes (hPSC-CMs) is key for advancing their utility for cellular disease models …

Current xeno-free and chemically defined methods for the differentiation of hPSCs (human
pluripotent stem cells) into cardiomyocytes are not efficient and are sometimes not …

Background Biomaterials can improve cardiac repair combined with transplantation of bone
marrow mononuclear cells (BMMNCs). In this study, we compared the phenotype and …

Distinct electrophysiological phenotypes are exhibited by biological cells that have
differentiated into particular cell types. The usual approach when simulating the cardiac …

Cardiomyocytes (CMs) derived from human embryonic stem cells (hESCs) or induced
pluripotent stem cells (iPSCs) are used to study cardiogenesis and mechanisms of heart …

Numerous drugs had to be removed from the market because of their potential to induce the
life-threatening ventricular tachyarrhythmia Torsades de Pointes (TdP). To prevent …

Elimination of primary cilia in cardiac neural crest cell (CNCC) progenitors is hypothesized
to cause a variety of congenital heart defects (CHDs), including atrioventricular septal …