We report the de novo asymmetric synthesis of the 3, 6-dideoxy sugars abequose, paratose,
and tyvelose from 2-acetylfuran. Conversion of this readily available ketone to a pyranone …

The development and application of the asymmetric synthesis of oligosaccharides from
achiral starting materials is reviewed. This de novo asymmetric approach centers around the …

Described herein are syntheses of the naturally occurring polyketides (−)-tetrapetalones A
and C and their respective enantiomers. The employed strategy involves initial assembly of …

Cardiac glycosides (CGs) are bioactive compounds originally used to treat heart diseases,
but recent studies have demonstrated their anticancer activity. We previously demonstrated …

Abstract Background Cardiac glycosides (CGs), such as digitoxin, are traditionally used for
treatment of congestive heart failure; recently they also gained attention for their anticancer …

Malaria is a prevalent and lethal disease. The fast emergence and spread of resistance to
current therapies is a major concern and the development of a novel line of therapy that …

An asymmetric approach toward the synthesis of the marine natural product aspergillide‐C
has been developed. The convergent asymmetric synthesis uses two asymmetric Noyori …

A practical one pot alkylative carboxylation of 2-acetylfuran was developed. The reaction
was optimized for the synthesis of methyl β-ketoesters. The β-keto-ester product was used in …

The various methods for the de novo asymmetric synthesis of the pyranose sugars are
surveyed in this update of the 2013 Advances in Carbohydrate Chemistry and Biochemistry …

An effort toward the total synthesis of the polyketide natural product EBC-23 is reported. The
asymmetric approach is convergent and uses a late-stage Claisen-like enolate/acid chloride …