The glycopeptide antimicrobials are a group of natural product and semisynthetic
glycosylated peptides that show antibacterial activity against Gram-positive organisms …

Tigecycline is unique glycylcycline class of semisynthetic antimicrobial agents developed for
the treatment of polymicrobial infections caused by multidrug-resistant Gram-positive and …

Microorganisms are remarkable producers of a wide diversity of natural products that
significantly improve human health and well-being. Currently, these natural products …

Tigecycline is a new semisynthetic glycylcycline for the treatment of serious infections. Of the
glycylcyclines, tigecycline is the most studied and appears to hold promise as a new …

Coagulase-negative staphylococci (CNS) are a heterogenous group of Gram-positive cocci
that are widespread commensals among mammalia. Unlike their coagulase-positive …

The pharmacokinetics of tigecycline, when given as a 100-mg loading dose followed by 50
mg every 12 h, were determined in serum and blister fluid. The peak tigecycline …

The Tigecycline Evaluation and Surveillance Trial is a global surveillance study monitoring
the efficacy of tigecycline and comparators against clinically important pathogens. Between …

Background Tigecycline, a first-in-class broad-spectrum glycylcycline antibiotic, has broad-
spectrum in vitro activity against bacteria commonly encountered in complicated intra …

As a part of the Tigecycline Evaluation and Surveillance Trial (TEST), Gram-positive and
Gram-negative bacterial isolates were collected from 33 centers in Latin America (centers in …

The treatment of complicated intra-abdominal infections continues to challenge physicians,
primarily because of the polymicrobial nature of these infections coupled with the high risk of …