Insulin resistance in glomerular podocytes: potential mechanisms of induction
D Rogacka - Archives of Biochemistry and Biophysics, 2021 - Elsevier
Glomerular podocytes are a target for the actions of insulin. Accumulating evidence
indicates that exposure to nutrient overload induces insulin resistance in these cells …
indicates that exposure to nutrient overload induces insulin resistance in these cells …
Beneficial effects of metformin on glomerular podocytes in diabetes
D Rogacka, A Piwkowska - Biochemical Pharmacology, 2021 - Elsevier
Podocytes and their foot processes form an important cellular layer of the glomerular barrier
involved in regulating glomerular permeability. Disturbances in podocyte function play a …
involved in regulating glomerular permeability. Disturbances in podocyte function play a …
Vitamin D3 ameliorates podocyte injury through the nephrin signalling pathway
O Trohatou, EF Tsilibary, A Charonis… - Journal of cellular …, 2017 - Wiley Online Library
Renal podocytes form the main filtration barrier possessing unique phenotype maintained
by proteins including podocalyxin and nephrin, which are modulated in pathological …
by proteins including podocalyxin and nephrin, which are modulated in pathological …
High Glucose Impairs Insulin Signaling in the Glomerulus: An In Vitro and Ex Vivo Approach
EN Katsoulieris, GI Drossopoulou, ES Kotsopoulou… - PLoS …, 2016 - journals.plos.org
Objective Chronic hyperglycaemia, as seen in type II diabetes, results in both morphological
and functional impairments of podocytes in the kidney. We investigated the effects of high …
and functional impairments of podocytes in the kidney. We investigated the effects of high …
Metformin ameliorates podocyte damage by restoring renal tissue podocalyxin expression in type 2 diabetic rats
L Zhai, J Gu, D Yang, W Wang… - Journal of diabetes …, 2015 - Wiley Online Library
Podocalyxin (PCX) is a signature molecule of the glomerular podocyte and of maintaining
integrity of filtration function of glomerulus. The aim of this study was to observe the effect of …
integrity of filtration function of glomerulus. The aim of this study was to observe the effect of …
[HTML][HTML] Functional annotation and enrichment analysis of differentially expressed serum proteins in patients with type 2 diabetes after dapagliflozin
YX Zhao, S Borjigin, ZL Yan - World Journal of Diabetes, 2022 - ncbi.nlm.nih.gov
BACKGROUND Only 50% of patients with type 2 diabetes mellitus (T2DM) can control their
blood glucose levels. Dapagliflozin is a selective inhibitor of sodium-glucose co-transporter …
blood glucose levels. Dapagliflozin is a selective inhibitor of sodium-glucose co-transporter …
Vitamin D receptor activators upregulate and rescue podocalyxin expression in high glucose-treated human podocytes
SN Verouti, EC Tsilibary, E Fragopoulou… - Nephron Experimental …, 2013 - karger.com
Background: Vitamin D is beneficial in human and experimental chronic kidney disease, the
leading cause of which is diabetic nephropathy. Vitamin D through its receptor, VDR …
leading cause of which is diabetic nephropathy. Vitamin D through its receptor, VDR …
Focal and segmental glomerulosclerosis: multiple pathways are involved
A Meyrier - Seminars in Nephrology, 2011 - Elsevier
Focal segmental glomerulosclerosis (FSGS) is not a disease but a clinicopathologic entity.
The term FSGS itself is a misnomer because its lesions are not always focal, segmental, or …
The term FSGS itself is a misnomer because its lesions are not always focal, segmental, or …
In situ assessment of Mindin as a biomarker of podocyte lesions in diabetic nephropathy
ALMS Martins, AB Bernardes, VA Ferreira… - Plos one, 2023 - journals.plos.org
Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and end-stage
renal failure worldwide. Several mechanisms are involved in the pathogenesis of this …
renal failure worldwide. Several mechanisms are involved in the pathogenesis of this …