Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease …

The incidence of type 2 diabetes (T2D) has rapidly increased over recent decades, and T2D
has become a leading public health challenge in China. Compared with European …

摘要2 型糖尿病已经成为全球公共卫生的主要挑战. 迄今为止, 通过全基因组关联研究(genome‐
wide association studies, GWAS) 总共已经鉴定出了83 个2 型糖尿病易感位点. 为了发现2 …

Diabetes is a global epidemic. Long-term exposure to hyperglycemia can cause chronic
damage to various tissues. Thus, early diagnosis of diabetes is crucial. In this study, we …

Background Although obesity and diabetes commonly co-exist, the evidence base to
support obesity as the major driver of type 2 diabetes mellitus (T2DM), and the mechanisms …

Except in rare cases, obesity tends to be a consequence of both an unhealthy lifestyle and a
genetic susceptibility to gain weight. With more than 200 common genetic variants identified …

Metabolic diseases including type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver
disease (NAFLD), and metabolic syndrome (MetS) are alarming health burdens around the …

Objective: High prevalence of diabetes mellitus (DM) along with the poor health outcomes
and the escalated costs of treatment and care poses the need to focus on prevention, early …

Genome-wide association studies (GWAS) may have reached their limit of detecting
common type 2 diabetes (T2D)–associated genetic variation. We evaluated the performance …

In observational studies, type-2 diabetes (T2D) is associated with an increased risk of
coronary heart disease (CHD), yet interventional trials have shown no clear effect of glucose …