[HTML][HTML] Levosimendan beyond inotropy and acute heart failure: evidence of pleiotropic effects on the heart and other organs: an expert panel position paper

D Farmakis, J Alvarez, TB Gal, D Brito, F Fedele… - International Journal of …, 2016 - Elsevier
Levosimendan is a positive inotrope with vasodilating properties (inodilator) indicated for
decompensated heart failure (HF) patients with low cardiac output. Accumulated evidence …

Levosimendan reduces mortality in patients with severe sepsis and septic shock: a meta-analysis of randomized trials

A Zangrillo, A Putzu, F Monaco, A Oriani, G Frau… - Journal of Critical …, 2015 - Elsevier
Purpose There is controversy about the use of inotropes in the treatment of severe sepsis
and septic shock. The objective of this study was to evaluate if levosimendan, as compared …

Resolvin D1 protects mice from LPS-induced acute lung injury

B Wang, X Gong, J Wan, L Zhang, Z Zhang, H Li… - Pulmonary …, 2011 - Elsevier
Abstract Resolvin D1 (RvD1), an endogenous lipid molecule derived from docosahexaenoic
acid (DHA), has been described to promote inflammatory resolution. The present study …

Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study

A Morelli, A Donati, C Ertmer, S Rehberg, M Lange… - Critical Care, 2010 - Springer
Introduction The purpose of the present study was to investigate microcirculatory blood flow
in patients with septic shock treated with levosimendan as compared to an active …

[HTML][HTML] Levosimendan versus dobutamine in myocardial injury patients with septic shock: a randomized controlled trial

J Meng, M Hu, Z Lai, C Ji, X Xu, G Zhang… - … medical journal of …, 2016 - ncbi.nlm.nih.gov
Levosimendan Versus Dobutamine in Myocardial Injury Patients with Septic Shock: A
Randomized Controlled Trial - PMC Back to Top Skip to main content NIH NLM Logo Access …

Anti-inflammatory profile of levosimendan in cecal ligation-induced septic mice and in lipopolysaccharide-stimulated macrophages

Q Wang, H Yokoo, M Takashina, K Sakata… - Critical Care …, 2015 - journals.lww.com
Objectives: The calcium sensitizer levosimendan is used in treatment of decompensated
heart failure and may also exhibit anti-inflammatory properties. We examined whether …

Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis

S Yamashita, T Suzuki, K Iguchi, T Sakamoto… - Naunyn-Schmiedeberg's …, 2018 - Springer
Levosimendan and milrinone may be used in place of dobutamine to increase cardiac
output in septic patients with a low cardiac output due to impaired cardiac function. The …

Towards integrative physiological monitoring of the critically ill: from cardiovascular to microcirculatory and cellular function monitoring at the bedside

A Donati, D Tibboel, C Ince - Critical care, 2013 - Springer
Current hemodynamic monitoring of critically ill patients is mainly focused on monitoring of
pressure-derived hemodynamic variables related to systemic circulation. Increasingly …

Protective effects of asiaticoside on septic lung injury in mice

L Zhang, J Zheng, L Zhang, X Gong, H Huang… - Experimental and …, 2011 - Elsevier
Asiaticoside (AS), a major triterpenoid saponin component isolated from Centella asiatica,
has been described to exhibit antioxidant and anti-inflammatory activities. The present study …

Effect of intravenous infusion of dobutamine hydrochloride on the development of early postoperative cognitive dysfunction in elderly patients via inhibiting the release …

D Sun, L Yang, Y Wu, R Liu, J Han, L Wang - European journal of …, 2014 - Elsevier
To investigate the effects of dobutamine hydrochloride on early postoperative cognitive
dysfunction (POCD) and plasma tumor necrosis factor (TNF)-α concentration in patients …