Nervous NDRGs: the N-myc downstream–regulated gene family in the central and peripheral nervous system

SL Schonkeren, M Massen, R van der Horst, A Koch… - neurogenetics, 2019 - Springer
The N-Myc downstream-regulated gene (NDRG) family consists of four members (NDRG1,
NDRG2, NDRG3, NDRG4) that are differentially expressed in various organs and function in …

NDRGs in Breast Cancer: A Review and In Silico Analysis

ES Villodre, APN Nguyen, BG Debeb - Cancers, 2024 - mdpi.com
Simple Summary Breast cancer is the most common cancer in women and one of the
deadliest. While survival rates for patients with breast cancer have seen notable …

MORC 2 promotes development of an aggressive colorectal cancer phenotype through inhibition of NDRG 1

J Liu, Y Shao, Y He, K Ning, X Cui, F Liu… - Cancer …, 2019 - Wiley Online Library
MORC 2 (microrchidia family CW‐type zinc finger 2) is a newly identified chromatin
remodeling protein that functions in diverse biological processes including gene …

O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT

G Zhu, M Qian, L Lu, Y Chen, X Zhang, Q Wu… - …, 2019 - academic.oup.com
Emerging studies have revealed that O-GlcNAcylation plays pivotal roles in the
tumorigenesis of colorectal cancers (CRCs). However, the underlying mechanism still …

NDRG1 regulates osteosarcoma cells via mediating the mitochondrial function and CSCs differentiation

T Zhao, Y Meng, Y Wang, W Wang - Journal of Orthopaedic Surgery and …, 2021 - Springer
Abstract Background Cancer stem cells (CSCs) are mainly contributed to malignancy
metastatic potential and resistant therapy of osteosarcoma (OS). The mitochondria-related …

Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2

N Vaes, SL Schonkeren, G Rademakers… - EMBO …, 2021 - embopress.org
Abstract The N‐Myc Downstream‐Regulated Gene 4 (NDRG4), a prominent biomarker for
colorectal cancer (CRC), is specifically expressed by enteric neurons. Considering that …

MicroRNA-940 restricts the expression of metastasis-associated gene MACC1 and enhances the antitumor effect of Anlotinib on colorectal cancer

Y Wang, M Zhao, H Zhao, S Cheng, R Bai… - OncoTargets and …, 2019 - Taylor & Francis
Background Metastasis-associated with colon cancer-1 (MACC1) is an important regulator
that promotes colorectal cancer (CRC) cells' proliferation and distant metastasis. Therefore …

[HTML][HTML] N-myc downstream regulated gene 1 inhibition of tumor progression in Caco2 cells

YX He, H Shen, YZ Ji, HR Hua, Y Zhu… - World Journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Invasion and migration are the irreversible stages of colorectal cancer
(CRC). The key is to find a sensitive, reliable molecular marker that can predict the migration …

Positive association of rs1049694 allele G located in NDRG1 with the incidence of gastric cancer and metastasis

H Gharazi, H Tabatabaeian, K Ghaedi, M Houshmand… - Gene reports, 2020 - Elsevier
Background and purpose One of the most prevalent cancers in the world and Iran is gastric
cancer with a high degree of lethality. There are many environmental factors and genes …

N-MYC Downstream Regulated Gene 4 (NDRG4), a Frequent Downregulated Gene through DNA Hypermethylation, plays a Tumor Suppressive Role in Esophageal …

L Cao, T Hu, H Lu, D Peng - Cancers, 2020 - mdpi.com
Simple Summary Esophageal adenocarcinoma has become a major clinical challenge in
the western world due to its rapid increasing incidence and poor overall prognosis …