Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Progressive DNA damage and mitochondrial decline are both considered to be prime
instigators of natural ageing. Traditionally, these two pathways have been viewed largely in …

In mammals, maintenance of the linear chromosome ends (or telomeres) involves faithful
replication of genetic materials and protection against DNA damage signals, to ensure …

Mitochondrial functions and telomere functions have mostly been studied independently. In
recent years, it, however, has become clear that there are intimate links between …

Spaceflight-induced changes in astronaut telomeres have garnered significant attention in
recent years. While plants represent an essential component of future long-duration space …

Shortened telomeres have been linked to numerous chronic diseases, most importantly
coronary artery disease, but the underlying mechanisms remain ill defined. Loss-of-function …

Telomerase activity is essential for human cancer cells in order to maintain telomeres and
provide unlimited proliferation potential and cellular immortality. However, additional non …

Most cancer cells express high levels of telomerase and proliferate indefinitely. In addition to
its telomere maintenance function, telomerase also has a pro-survival function resulting in …

Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as
the nucleus, but details about its biology and function in the organelle remain largely …

Telomere biology plays a critical and complex role in the initiation and progression of
cancer. Although telomere dysfunction resulting from replicative attrition constrains tumor …