The slow death of the concept of schizophrenia and the painful birth of the psychosis spectrum

S Guloksuz, J van Os - Psychological medicine, 2018 - cambridge.org
The concept of schizophrenia only covers the 30% poor outcome fraction of a much broader
multidimensional psychotic syndrome, yet paradoxically has become the dominant prism …

Association of psychotic experiences with subsequent risk of suicidal ideation, suicide attempts, and suicide deaths: a systematic review and meta-analysis of …

K Yates, U Lång, M Cederlöf, F Boland, P Taylor… - JAMA …, 2019 - jamanetwork.com
Importance Recent research has highlighted that psychotic experiences are far more
prevalent than psychotic disorders and associated with the full range of mental disorders. A …

Beyond the “at risk mental state” concept: transitioning to transdiagnostic psychiatry

PD McGorry, JA Hartmann, R Spooner… - World …, 2018 - Wiley Online Library
The “at risk mental state” for psychosis approach has been a catalytic, highly productive
research paradigm over the last 25 years. In this paper we review that paradigm and …

Psychosis as a transdiagnostic and extended phenotype in the general population

J Van Os, U Reininghaus - World Psychiatry, 2016 - Wiley Online Library
A large body of research indicates that weak expressions of positive psychotic symptoms
(“psychotic experiences”) can be measured in the general population, and likely represent …

EPA guidance on the early detection of clinical high risk states of psychoses

F Schultze-Lutter, C Michel, SJ Schmidt… - European …, 2015 - cambridge.org
The aim of this guidance paper of the European Psychiatric Association is to provide
evidence-based recommendations on the early detection of a clinical high risk (CHR) for …

A critique of the “ultra‐high risk” and “transition” paradigm

J Van Os, S Guloksuz - World Psychiatry, 2017 - Wiley Online Library
The transdiagnostic expression of psychotic experiences in common mental disorder
(anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a …

Childhood and adolescent psychotic experiences and risk of mental disorder: a systematic review and meta-analysis

C Healy, R Brannigan, N Dooley, H Coughlan… - Psychological …, 2019 - cambridge.org
BackgroundPsychotic experiences (PEs) are common in childhood and adolescence and
their association with mental disorders is well-established. We aim to conduct a quantitative …

Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis

JL Shah, N Jones, J van Os, PD McGorry… - The Lancet …, 2022 - thelancet.com
Challenges associated with operationalising services for the at-risk mental state for
psychosis solely in that same diagnostic silo are increasingly well recognised—namely, the …

The past and future of delusions research: from the inexplicable to the treatable

PA Garety, D Freeman - The British Journal of Psychiatry, 2013 - cambridge.org
BackgroundProblems with the diagnosis and treatment of schizophrenia have led for a call
to change strategy and focus on individual psychotic experiences. In recent years, research …

Childhood trauma and psychosis in a prospective cohort study: cause, effect, and directionality

I Kelleher, H Keeley, P Corcoran… - American journal of …, 2013 - Am Psychiatric Assoc
Objective Using longitudinal and prospective measures, the authors assessed the
relationship between childhood trauma and psychotic experiences, addressing the following …