It is estimated that more than 339 million people worldwide suffer from asthma. The leading
cause of asthma development is the breakdown of immune tolerance to inhaled allergens …

IgG4, the least represented human IgG subclass in serum, is an intriguing antibody with
unique biological properties, such as the ability to undergo Fab‐arm exchange and limit …

Pneumologists, Sleep and Respiratory Physicians (BdP)(Sebastian Böing), Professional
Association of German Dermatologists (BVDD)(Klaus Strömer) were taking part in the …

Background Most children with detectable peanut-specific IgE (P-sIgE) are not allergic to
peanut. We addressed 2 non–mutually exclusive hypotheses for the discrepancy between …

Host-induced antibodies and their contributions to cancer inflammation are largely
unexplored. IgG4 subclass antibodies are present in IL-10–driven Th2 immune responses in …

The role of maternal immune responses in tolerance induction is poorly understood. To
study whether maternal allergen sensitization affects offspring susceptibility to food allergy …

Antibodies of IgG4 subclass are exceptional players of the immune system, as they are
considered to be immunologically inert and functionally monovalent, and as such may be …

Immunoglobulin E (IgE)-associated allergy is the most common immune disorder. More than
30% of the population suffer from symptoms of allergy which are often severe, disabling, and …

IgG4 autoimmune diseases are characterized by the presence of antigen-specific
autoantibodies of the IgG4 subclass and contain well-characterized diseases such as …

Background Sublingual administration of Phleum pratense allergen immunotherapy (SLIT)
tablets is a clinically efficient treatment for grass pollen–induced rhinoconjunctivitis. This …