The plasminogen activator (PA) system is an extracellular proteolytic enzyme system
associated with various physiological and pathophysiological processes. A large body of …

Introduction: The urokinase plasminogen activator (uPA) system, comprising the serine
protease uPA, its cognate receptor, uPAR, and two endogenous inhibitors, plasminogen …

The invasive ability of tumor cells plays a key role in prostate cancer metastasis and is a
major cause of treatment failure. Urokinase plasminogen activator-(uPA) and its receptor …

Prostate cancer is one of the most commonly diagnosed cancers and the second leading
cause of cancer deaths in Americans. The high mortality rate is mainly attributed to the …

The urokinase plasminogen activator receptor (uPAR) has been implicated in the growth,
metastasis, and angiogenesis of several solid and hemotologic malignancies. uPAR is part …

The urokinase-mediated plasminogen activation (PA) system is involved in many
physiological and pathological events that include cell migration and tissue remodelling …

Background Cathepsins represent a group of proteases involved in determining the
metastatic potential of cancer cells. Among these are cysteinyl-(eg cathepsin B and …

[Frontiers in Bioscience 14, 4575-4587, January 1, 2009] 4575 The urokinase receptor as an
entertainer of signal transduction Si Page 1 [Frontiers in Bioscience 14, 4575-4587, January 1 …

Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for
metastasis, and overexpression of these molecules is strongly correlated with poor …

The urokinase plasminogen activator receptor (uPAR) mediates cell motility and tissue
remodeling. Although uPAR may be expressed transiently in many tissues during …