Nociceptin/orphanin FQ receptor structure, signaling, ligands, functions, and interactions with opioid systems
L Toll, MR Bruchas, BM Cox, NT Zaveri - Pharmacological reviews, 2016 - ASPET
The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently
discovered member of the opioid receptor family and, together with its endogenous ligand …
discovered member of the opioid receptor family and, together with its endogenous ligand …
The neurobiology and control of anxious states
MJ Millan - Progress in neurobiology, 2003 - Elsevier
Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
产后抑郁症病因, 诊断及防治的研究进展
崔才三， 隋京美， 韩丹青 - 现代妇产科进展, 2005 - cqvip.com
产后抑郁症的发病率高, 病因复杂, 主要有内分泌因素, 遗传因素, 心理因素及社会因素等.
目前国内外尚无特异的实验室指标和统一的诊断标准, 多依据各种症状的自评量表 …
目前国内外尚无特异的实验室指标和统一的诊断标准, 多依据各种症状的自评量表 …
Neuropeptides as synaptic transmitters
Neuropeptides are small protein molecules (composed of 3–100 amino-acid residues) that
have been localized to discrete cell populations of central and peripheral neurons. In most …
have been localized to discrete cell populations of central and peripheral neurons. In most …
Functional plasticity of the N/OFQ‐NOP receptor system determines analgesic properties of NOP receptor agonists
W Schröder, DG Lambert, MC Ko… - British journal of …, 2014 - Wiley Online Library
Despite high sequence similarity between NOP (nociceptin/orphanin FQ opioid peptide) and
opioid receptors, marked differences in endogenous ligand selectivity, signal transduction …
opioid receptors, marked differences in endogenous ligand selectivity, signal transduction …
Low-dose naltrexone for disease prevention and quality of life
N Brown, J Panksepp - Medical hypotheses, 2009 - Elsevier
The use of low-dose naltrexone (LDN) for the treatment and prophylaxis of various bodily
disorders is discussed. Accumulating evidence suggests that LDN can promote health …
disorders is discussed. Accumulating evidence suggests that LDN can promote health …
Costorage and coexistence of neuropeptides in the mammalian CNS
A Merighi - Progress in neurobiology, 2002 - Elsevier
The term neuropeptides commonly refers to a relatively large number of biologically active
molecules that have been localized to discrete cell populations of central and peripheral …
molecules that have been localized to discrete cell populations of central and peripheral …
The effects of low dose naltrexone on opioid induced hyperalgesia and fibromyalgia
D Jackson, S Singh, Y Zhang-James, S Faraone… - Frontiers in …, 2021 - frontiersin.org
Objectives: While opioids temporarily alleviate pain, the overshoot of balancing pain drivers
may increase pain, leading to opioid induced hyperalgesia (OIH). Our goal was to find out …
may increase pain, leading to opioid induced hyperalgesia (OIH). Our goal was to find out …
Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs
EC Gavioli - Pharmacology & therapeutics, 2013 - Elsevier
Abstract Nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) were identified in the mid
90s as a novel peptidergic system structurally related to opioids. A growing body of …
90s as a novel peptidergic system structurally related to opioids. A growing body of …
Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse
Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an
endogenous ligand for the NOP receptor, ample evidence has revealed unique functional …
endogenous ligand for the NOP receptor, ample evidence has revealed unique functional …