Antioxidant, anti-inflammatory, anti-menopausal, and anti-cancer effects of lignans and their metabolites
Since chronic inflammation can be seen in severe, long-lasting diseases such as cancer,
there is a high demand for effective methods to modulate inflammatory responses. Among …
there is a high demand for effective methods to modulate inflammatory responses. Among …
Cachexia: A systemic consequence of progressive, unresolved disease
Cachexia, a systemic wasting condition, is considered a late consequence of diseases,
including cancer, organ failure, or infections, and contributes to significant morbidity and …
including cancer, organ failure, or infections, and contributes to significant morbidity and …
Therapeutic strategies targeting connexins
The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …
Connexins in cardiovascular and neurovascular health and disease: pharmacological implications
Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
Ginsenosides from Panax ginseng as Key Modulators of NF-κB Signaling Are Powerful Anti-Inflammatory and Anticancer Agents
Nuclear factor kappa B (NF-κB) signaling pathways progress inflammation and immune cell
differentiation in the host immune response; however, the uncontrollable stimulation of NF …
differentiation in the host immune response; however, the uncontrollable stimulation of NF …
Amelioration of muscle wasting by glucagon‐like peptide‐1 receptor agonist in muscle atrophy
Y Hong, JH Lee, KW Jeong, CS Choi… - Journal of cachexia …, 2019 - Wiley Online Library
Background Skeletal muscle atrophy is defined as a reduction of muscle mass caused by
excessive protein degradation. However, the development of therapeutic interventions is still …
excessive protein degradation. However, the development of therapeutic interventions is still …
Ubiquitin ligases at the heart of skeletal muscle atrophy control
D Peris-Moreno, L Cussonneau, L Combaret, C Polge… - Molecules, 2021 - mdpi.com
Skeletal muscle loss is a detrimental side-effect of numerous chronic diseases that
dramatically increases mortality and morbidity. The alteration of protein homeostasis is …
dramatically increases mortality and morbidity. The alteration of protein homeostasis is …
[HTML][HTML] The role of connexin and pannexin channels in perinatal brain injury and inflammation
Perinatal brain injury remains a major cause of death and life-long disability. Perinatal brain
injury is typically associated with hypoxia-ischemia and/or infection/inflammation. Both …
injury is typically associated with hypoxia-ischemia and/or infection/inflammation. Both …
Tonabersat prevents inflammatory damage in the central nervous system by blocking connexin43 hemichannels
The cis benzopyran compound tonabersat (SB-220453) has previously been reported to
inhibit connexin26 expression in the brain by attenuating the p38-mitogen-activated protein …
inhibit connexin26 expression in the brain by attenuating the p38-mitogen-activated protein …
Dieckol attenuated glucocorticoid-induced muscle atrophy by decreasing NLRP3 inflammasome and pyroptosis
S Oh, J Yang, C Park, K Son, K Byun - International journal of molecular …, 2021 - mdpi.com
Dexamethasone (Dexa), frequently used as an anti-inflammatory agent, paradoxically leads
to muscle inflammation and muscle atrophy. Receptor for advanced glycation end products …
to muscle inflammation and muscle atrophy. Receptor for advanced glycation end products …