Functional Exploration of Conserved Sequences in the Distal Face of Angiotensinogen—Brief Report
BACKGROUND: Angiotensinogen (AGT) is an essential component in the renin-angiotensin
system. AGT has highly conserved sequences in the loop and β-sheet regions among …
system. AGT has highly conserved sequences in the loop and β-sheet regions among …
[HTML][HTML] Trehalose promotes atherosclerosis regression in female mice
S Robichaud, V Rochon, C Emerton, T Laval… - Frontiers in …, 2024 - frontiersin.org
Introduction Atherosclerosis is a chronic inflammatory disease caused by the deposition of
lipids within the artery wall. During atherogenesis, efficient autophagy is needed to facilitate …
lipids within the artery wall. During atherogenesis, efficient autophagy is needed to facilitate …
[HTML][HTML] Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice
D Ye, C Wu, L Cai, DA Howatt, CL Liang… - Global translational …, 2023 - ncbi.nlm.nih.gov
Hepatocyte-derived angiotensinogen (AGT) is the precursor of angiotensin II (AngII). We
determined the effects of hepatocyte-specific (N-acetylgalactosamine-conjugated) antisense …
determined the effects of hepatocyte-specific (N-acetylgalactosamine-conjugated) antisense …
[HTML][HTML] Renal Proximal Tubule Cell-specific Megalin Deletion Does Not Affect Atherosclerosis But Induces Tubulointerstitial Nephritis in Mice Fed Western Diet
Background: Pharmacological inhibition of megalin (also known as low-density lipoprotein
receptor-related protein 2: LRP2) attenuates atherosclerosis in hypercholesterolemic mice …
receptor-related protein 2: LRP2) attenuates atherosclerosis in hypercholesterolemic mice …
[HTML][HTML] Endothelial nitric oxide synthase (eNOS) S1176 phosphorylation status governs atherosclerotic lesion formation
TD Nguyen, NT Rahman, WC Sessa… - Frontiers in …, 2023 - frontiersin.org
Objective We have previously demonstrated the in vivo importance of the Akt-eNOS
substrate-kinase relationship, as defective postnatal angiogenesis characteristic of global …
substrate-kinase relationship, as defective postnatal angiogenesis characteristic of global …
Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice
Background and objective Whole body manipulation of the renin-angiotensin system (RAS)
consistently exerts profound effects on experimental atherosclerosis development. A deficit …
consistently exerts profound effects on experimental atherosclerosis development. A deficit …
Application of Machine Learning and Virtual Reality for Volumetric Analysis of Arterial Lesions
AE Cartaya, S Maiocchi, NE Buglak, S Torzone… - bioRxiv, 2022 - biorxiv.org
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. Preclinical
studies to research and validate therapeutic interventions for CVD often depend on two …
studies to research and validate therapeutic interventions for CVD often depend on two …
Renal Proximal Tubule Cell-specific Megalin Deletion Induces Tubulointerstitial Nephritis in Mice Fed Western Diet.
N Amioka, MK Franklin, M Kukida… - Biorxiv: the Preprint …, 2024 - europepmc.org
Pharmacological inhibition of megalin (also known as low-density lipoprotein receptor-
related protein 2: LRP2) attenuates atherosclerosis in hypercholesterolemic mice. Since …
related protein 2: LRP2) attenuates atherosclerosis in hypercholesterolemic mice. Since …
[PDF][PDF] Application of Machine Learning for Volumetric Analysis of Atherosclerotic Burden
EM Bahnson - scholar.archive.org
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. Preclinical
studies to research and validate therapeutic interventions for CVD often depend on …
studies to research and validate therapeutic interventions for CVD often depend on …
[引用][C] Inaugural editorial: A new platform dedicated to promote bench-to-bedside translation
L Zheng - Global Transl Med, 2022 - December 30, Online