Glycoconjugates: synthesis, functional studies, and therapeutic developments
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
Peptide-based vaccines: current progress and future challenges
RJ Malonis, JR Lai, O Vergnolle - Chemical reviews, 2019 - ACS Publications
Vaccines have had a profound impact on the management and prevention of infectious
disease. In addition, the development of vaccines against chronic diseases has attracted …
disease. In addition, the development of vaccines against chronic diseases has attracted …
Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B. 1.1. 529
The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.
1.1. 529 (Omicron) variant and its resistance to neutralization by vaccinee and convalescent …
1.1. 529 (Omicron) variant and its resistance to neutralization by vaccinee and convalescent …
Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants
L Wang, T Zhou, Y Zhang, ES Yang, CA Schramm… - Science, 2021 - science.org
INTRODUCTION Worldwide appearance of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) variants of concern (VOCs) with increased transmissibility and resistance to …
2 (SARS-CoV-2) variants of concern (VOCs) with increased transmissibility and resistance to …
Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity
Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
Broadly neutralizing antibodies to HIV and their role in vaccine design
DR Burton, L Hangartner - Annual review of immunology, 2016 - annualreviews.org
HIV employs multiple means to evade the humoral immune response, particularly the
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
HIV-1 vaccines based on antibody identification, B cell ontogeny, and epitope structure
PD Kwong, JR Mascola - Immunity, 2018 - cell.com
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
Biological roles of glycans
A Varki - Glycobiology, 2017 - academic.oup.com
Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …
Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques
L Xu, A Pegu, E Rao, N Doria-Rose, J Beninga… - Science, 2017 - science.org
The development of an effective AIDS vaccine has been challenging because of viral
genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We …
genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We …