Phase-contrast X-ray lung imaging has broken new ground in preclinical respiratory
research by improving contrast at air/tissue interfaces. To minimize blur from respiratory …

The complexity of lung diseases makes pre-clinical in vivo respiratory research in mouse
lungs of great importance for a better understanding of physiology and therapeutic effects …

The aim of this study was to assess the association between regional tidal volume (Vt),
regional functional residual capacity (FRC), and the expression of genes linked with …

We have developed an x-ray imaging system for in vivo four-dimensional computed
tomography (4DCT) of small animals for pre-clinical lung investigations. Our customized …

The quantification of airway compliance (C aw) is essential to the study of airway alterations
in disease models. However, the required measurements of airway pressure and volume …

This chapter reviews the main categories of methods that have been developed for
preclinical and clinical imaging applications. The methods covered here are all based on …

Imaging in small animal models of lung disease is challenging, as existing technologies are
limited either by resolution or by the terminal nature of the imaging approach. Here, we …

Despite decades of research, studies investigating the physiological alterations caused by
an acute bout of inflammation induced by exposing the lung to lipopolysaccharide have …

Both overdistension and atelectasis contribute to lung injury and mortality during mechanical
ventilation. It has been proposed that combinations of tidal volume and end-expiratory lung …

Noninvasive imaging of the murine pulmonary vasculature is challenging due to the small
size of the animal, limits of resolution of the imaging technology, terminal nature of the …