Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …

Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

Phagocytosis of tubercle bacilli by antigen‐presenting cells in human lung alveoli initiates a
complex infection process by Mycobacterium tuberculosis and a potentially protective …

One of the main features of the immune response to M. Tuberculosis is the formation of an
organized structure called granuloma. It consists mainly in the recruitment at the infectious …

The mycobacterial cord factor trehalose-6, 6-dimycolate (TDM) and its synthetic analog
trehalose-6, 6-dibehenate (TDB) are potent adjuvants for Th1/Th17 vaccination that activate …

Bacteria naturally release membrane vesicles (MVs) under a variety of growth environments.
Their production is associated with virulence due to their capacity to concentrate toxins and …

Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …

Approximately one third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich …

Background Saponins are glycosides which, after acid hydrolysis, liberate sugar (s) and an
aglycone (sapogenin) which can be triterpenoid or steroidal in nature. Steroidal saponins …