Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …

Dementia is a frequent problem encountered in advanced stages of Parkinson disease (PD).
In recent years, research has focused on the pre-dementia stages of cognitive impairment in …

Background Synapse damage and loss are fundamental to the pathophysiology of
Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to …

Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Alzheimer's disease (AD) is one of the most common forms of dementia. Despite a wealth of
knowledge on the molecular mechanisms involved in AD, current treatments have mainly …

Background Neuroinflammation plays an important role in the onset and progression of
neurodegenerative diseases such as Alzheimer's disease. Lipopolysaccharide (LPS …

Background Gut homeostasis, including intestinal immunity and microbiome, is essential for
cognitive function via the gut-brain axis. This axis is altered in high-fat diet (HFD)-induced …

Abstract See Attems and Jellinger (doi: 10.1093/brain/awx360) for a scientific commentary
on this article. Cognitive changes occurring throughout the pathogenesis of …

Alzheimer's disease (AD) is the most common form of dementia, which is progressively
affecting elderly people. The dyshomeostasis of biometals and accumulation of toxic metals …